ID   NXNL1_XENLA             Reviewed;         215 AA.
AC   Q68EV9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Nucleoredoxin-like protein 1;
GN   Name=nxnl1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in retinal cone photoreceptor
CC       survival (By similarity). May play a role in cone cell viability,
CC       slowing down cone degeneration, does not seem to play a role in
CC       degenerating rods (By similarity). {ECO:0000250|UniProtKB:Q8VC33}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC       segment {ECO:0000250|UniProtKB:Q8VC33}.
CC   -!- SIMILARITY: Belongs to the nucleoredoxin family. {ECO:0000305}.
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DR   EMBL; BC080091; AAH80091.1; -; mRNA.
DR   RefSeq; NP_001087547.1; NM_001094078.1.
DR   AlphaFoldDB; Q68EV9; -.
DR   SMR; Q68EV9; -.
DR   DNASU; 447371; -.
DR   GeneID; 447371; -.
DR   KEGG; xla:447371; -.
DR   CTD; 447371; -.
DR   Xenbase; XB-GENE-961005; nxnl1.L.
DR   OMA; WLFLPFQ; -.
DR   OrthoDB; 1624076at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447371; Expressed in camera-type eye and 1 other tissue.
DR   GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0045494; P:photoreceptor cell maintenance; ISS:UniProtKB.
DR   InterPro; IPR029520; RdCVF.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR47109; PTHR47109; 1.
DR   Pfam; PF13905; Thioredoxin_8; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Nucleoredoxin-like protein 1"
FT                   /id="PRO_0000319546"
FT   DOMAIN          1..165
FT                   /note="Thioredoxin; atypical"
FT   REGION          185..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  25400 MW;  45DCA62ACB0D9454 CRC64;
     MADLFLDKIL VKNNRDQDEL DTEREIWERL ENRVILLFFA KSRSSQCQEF APLLKDFFVR
     LTDEFYVDRS SQLALVYVSL DQSEEEQERF LKDMPKRWLF VPFKDEEFRR NLEAQFSVSR
     VPVLVVLKPS GHVISFNAVD EVVRLGPPCF KNWQEVSEII DRSFLLPEFT DDRAGRSMTD
     PIRRIKYKDE TTNEKKKRKH CDDEDEGGGG GTEFF