NXP20_MOUSE
ID NXP20_MOUSE Reviewed; 569 AA.
AC Q9D281; Q8BMQ0; Q8R2U1; Q9D3K6;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein Noxp20;
DE AltName: Full=Nervous system overexpressed protein 20;
DE AltName: Full=Protein FAM114A1;
GN Name=Fam114a1; Synonyms=Noxp20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv;
RX PubMed=17029606; DOI=10.1111/j.1471-4159.2006.04093.x;
RA Boucquey M.F.A., De Plaen E., Locker M., Poliard A., Mouillet-Richard S.,
RA Boon T., Kellermann O.;
RT "Noxp20 and Noxp70, two new markers of early neuronal differentiation,
RT detected in teratocarcinoma-derived neuroectodermic precursor cells.";
RL J. Neurochem. 99:657-669(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, Head, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-197, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in neuronal cell development.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Over-expressed in brain. Also detected in lung,
CC stomach, and in a lower extent in testis and thymus.
CC -!- DEVELOPMENTAL STAGE: At embryonic days 12 and 15, it is strongly
CC expressed in the ventricular and intermediate zones of the brain and of
CC the spinal cord. At postnatal day 10, it is detected in the dentate
CC gyrus, the hippocampus, the cerebellum and the olfactory bulb.
CC -!- SIMILARITY: Belongs to the FAM114 family. {ECO:0000305}.
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DR EMBL; AM162548; CAJ44264.1; -; mRNA.
DR EMBL; AK017336; BAB30694.1; -; mRNA.
DR EMBL; AK020262; BAB32046.1; -; mRNA.
DR EMBL; AK030360; BAC26919.1; -; mRNA.
DR EMBL; BC027235; AAH27235.1; -; mRNA.
DR EMBL; BC110359; AAI10360.1; -; mRNA.
DR CCDS; CCDS19304.1; -.
DR RefSeq; NP_080943.3; NM_026667.3.
DR AlphaFoldDB; Q9D281; -.
DR SMR; Q9D281; -.
DR BioGRID; 212793; 3.
DR STRING; 10090.ENSMUSP00000031080; -.
DR iPTMnet; Q9D281; -.
DR PhosphoSitePlus; Q9D281; -.
DR jPOST; Q9D281; -.
DR MaxQB; Q9D281; -.
DR PaxDb; Q9D281; -.
DR PeptideAtlas; Q9D281; -.
DR PRIDE; Q9D281; -.
DR ProteomicsDB; 294257; -.
DR Antibodypedia; 68341; 50 antibodies from 17 providers.
DR DNASU; 68303; -.
DR Ensembl; ENSMUST00000031080; ENSMUSP00000031080; ENSMUSG00000029185.
DR GeneID; 68303; -.
DR KEGG; mmu:68303; -.
DR UCSC; uc012dwn.1; mouse.
DR CTD; 92689; -.
DR MGI; MGI:1915553; Fam114a1.
DR VEuPathDB; HostDB:ENSMUSG00000029185; -.
DR eggNOG; ENOG502R83C; Eukaryota.
DR GeneTree; ENSGT00390000010054; -.
DR HOGENOM; CLU_035724_0_0_1; -.
DR InParanoid; Q9D281; -.
DR OMA; MCKEVGC; -.
DR OrthoDB; 947469at2759; -.
DR PhylomeDB; Q9D281; -.
DR TreeFam; TF324360; -.
DR BioGRID-ORCS; 68303; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Fam114a1; mouse.
DR PRO; PR:Q9D281; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D281; protein.
DR Bgee; ENSMUSG00000029185; Expressed in humerus cartilage element and 232 other tissues.
DR ExpressionAtlas; Q9D281; baseline and differential.
DR Genevisible; Q9D281; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR007998; DUF719.
DR PANTHER; PTHR12842; PTHR12842; 1.
DR Pfam; PF05334; DUF719; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..569
FT /note="Protein Noxp20"
FT /id="PRO_0000274562"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 197
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 262
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IWE2"
FT CONFLICT 374
FT /note="L -> P (in Ref. 2; BAC26919)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="E -> G (in Ref. 2; BAB30694)"
FT /evidence="ECO:0000305"
FT CONFLICT 568
FT /note="C -> S (in Ref. 3; AAH27235/AAI10360)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 61013 MW; 932ABA5C7380C2A5 CRC64;
MSDDARDTIA NGVGEDAAEM PNSDSPAEDA AEVQCGPATT SNEPAPDDHM EEQPEITAMC
AESTPPGILD QSKASAADET PLNGEVTEDT LVECVDSVSL EGDTGSEIPL KEQDDAAVDP
SSQAGRWAGW GSWGKSLLSS ASATVGHGLT AVKEKAGATL RIHSANSASP EGAPTDAENG
ISGNVTPDQD PARGPHTPPP PGAAGSRGML SALTNVVQNT GKSVLTGGLD ALEFIGKKTM
IVLAESDPGF KRTKTLMERT VSLSQMLREA KEKEKQRLAQ QLTVERTAHY GMLFDEYQGL
SHLEALEILS NESESKVQSF LTSLDGEKLE LLKNDLISIK DIFVAKESEN EANPEEQGLE
ESGEEFARML TELLFELHVA ATPDKLNKAM KKAHDWVEED QSVVSIDVAK GSEEEEKEEG
KEEKAEEPEE DKTGGQGAKT VEEVYMLSIE SLAEVTARCI EQLHKVAELI LHGQEEEKPA
QDQARVLIKL TTAMCNEVTS LSKKFTNSLT TVGSNKKAEV LNPMINSVFL EGSNSTTYVQ
DALQLLLPVL QVSHIRTSCL KATAQPDCS
