ID   NXPE1_RABIT             Reviewed;         540 AA.
AC   Q05004;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=NXPE family member 1;
DE   AltName: Full=Brush border protein AdRab-A;
DE   AltName: Full=Protein FAM55A;
DE   Flags: Precursor;
GN   Name=NXPE1; Synonyms=FAM55A;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Intestine;
RX   PubMed=8509424; DOI=10.1016/s0021-9258(18)31471-6;
RA   Boll W., Schmid-Chanda T., Semenza G., Mantei N.;
RT   "Messenger RNAs expressed in intestine of adult but not baby rabbits.
RT   Isolation of cognate cDNAs and characterization of a novel brush border
RT   protein with esterase and phospholipase activity.";
RL   J. Biol. Chem. 268:12901-12911(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Intestine, and to a lesser extent in kidney.
CC       {ECO:0000269|PubMed:8509424}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the intestine of adult but not baby
CC       rabbits. {ECO:0000269|PubMed:8509424}.
CC   -!- SIMILARITY: Belongs to the NXPE family. {ECO:0000305}.
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DR   EMBL; Z12840; CAA78302.1; -; mRNA.
DR   PIR; B45665; B45665.
DR   RefSeq; NP_001095182.1; NM_001101712.1.
DR   AlphaFoldDB; Q05004; -.
DR   STRING; 9986.ENSOCUP00000020329; -.
DR   GeneID; 100009342; -.
DR   KEGG; ocu:100009342; -.
DR   CTD; 120400; -.
DR   eggNOG; ENOG502QW5F; Eukaryota.
DR   InParanoid; Q05004; -.
DR   OrthoDB; 587284at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..540
FT                   /note="NXPE family member 1"
FT                   /id="PRO_0000020802"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        42
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        291
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   540 AA;  61889 MW;  EB65770EC869F25A CRC64;
     MLHKYLKLIC LLAAICVLCI ISQNSTKIWG ALKLPNSHYY SNTSMISSIP KMSVSPVKSL
     TETELRVKEI LEKLDRLIPP RPFTHVNTTT SATHSTATIL NPQDKYCVGD QLDILLEVRD
     YLGHQKEYGG DFLRARMFSP ALKAGASGKV TDFNNGTYLV SFTLFWEGQV SLSVLLIHPS
     EGASALWRAR NQGYDRIIFK GQFVNGTSHV FTECSLTLNS NTEECKYLNG RDQDVFYCMK
     PQHMPCEALT HVTSRNRDIS YLTSKEKNLF HRSKVGVEIM KNQHIDVSQC NKSKEVKEKC
     QIGMKIPVPG GYTLQGRWLT TFCNQIQLDT AKISGCLKGK LIYLMGDSTL RQWIYYLPKV
     MKTLKFFDLH ETGNFKKHLL LDAEKHTQIQ WKKHSHPFVT YQLFSVIDHG YIPQEIDRLI
     GDKDTVIVIT FGQHFRPFPI DIFIRRAISV RQAIERLFLR SPATKVIVKT ENIREMHIEA
     ERFGDFHGYI QYLTLKDIFK DLNVGVVDAW DMTIAYGTNN VHPPDQVIGN QINMFLNYIC