NXPE2_MOUSE
ID NXPE2_MOUSE Reviewed; 558 AA.
AC Q3U095; B2RU41; Q8BM95; Q9CX72;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=NXPE family member 2;
DE AltName: Full=Protein FAM55B;
GN Name=Nxpe2; Synonyms=Fam55b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum, and Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NXPE family. {ECO:0000305}.
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DR EMBL; AK019469; BAB31740.1; -; mRNA.
DR EMBL; AK033667; BAC28418.1; -; mRNA.
DR EMBL; AK157096; BAE33960.1; -; mRNA.
DR EMBL; CH466522; EDL25700.1; -; Genomic_DNA.
DR EMBL; BC140955; AAI40956.1; -; mRNA.
DR CCDS; CCDS23151.1; -.
DR RefSeq; NP_084345.2; NM_030069.3.
DR AlphaFoldDB; Q3U095; -.
DR BioGRID; 219283; 2.
DR STRING; 10090.ENSMUSP00000034527; -.
DR PhosphoSitePlus; Q3U095; -.
DR jPOST; Q3U095; -.
DR PaxDb; Q3U095; -.
DR PeptideAtlas; Q3U095; -.
DR PRIDE; Q3U095; -.
DR ProteomicsDB; 293792; -.
DR DNASU; 78252; -.
DR GeneID; 78252; -.
DR KEGG; mmu:78252; -.
DR UCSC; uc009phw.2; mouse.
DR CTD; 120406; -.
DR MGI; MGI:1925502; Nxpe2.
DR eggNOG; ENOG502QW5F; Eukaryota.
DR InParanoid; Q3U095; -.
DR OrthoDB; 587284at2759; -.
DR PhylomeDB; Q3U095; -.
DR TreeFam; TF329555; -.
DR BioGRID-ORCS; 78252; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q3U095; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q3U095; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR026845; NXPH/NXPE.
DR Pfam; PF06312; Neurexophilin; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..558
FT /note="NXPE family member 2"
FT /id="PRO_0000403788"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 20
FT /note="R -> Q (in Ref. 1; BAC28418/BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 31
FT /note="V -> A (in Ref. 1; BAC28418/BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 153..162
FT /note="IFSPAMKAGT -> MSSPALKAGA (in Ref. 1; BAC28418/
FT BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 176
FT /note="V -> I (in Ref. 1; BAC28418/BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="M -> I (in Ref. 3; AAI40956)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="G -> A (in Ref. 1; BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="L -> P (in Ref. 1; BAC28418/BAB31740)"
FT /evidence="ECO:0000305"
FT CONFLICT 384
FT /note="Y -> F (in Ref. 1; BAC28418/BAB31740)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 558 AA; 63966 MW; 7F8842A4471A2B00 CRC64;
MRRMLSPRIL LSSLPNASAR KLFLIVLIIF VFWVVFMTSK DHTEFMVHLN NRIILRRWSI
FKEFLHSEEL KNTPASVEAE LAVTAILEKL NQQIPPRPFQ THSSTTSAKQ STATIHNPQR
TYCVGDQLNV LLVAKDYFGN RKEYGGDFLR ARIFSPAMKA GTSGKVTDFN NGTYLVSFTL
FWEGPVSLSI LLMHPSEGVS ALWRARNRGY GKIIFTGQFL NGTSPVLTEC GLTLNTSAEL
CQYLDARDHE AFYCLKLPGV PCEALTHMTS KNSNISYLSL EEKLLFRRFN IGVEVVKNLS
IVVSLCNNKT NKKKKKCQIG METPSPGGYT LKGRWITAHC EQNEFRAIKD INNCLTRKLI
YLMGDSTLRQ WIYYLPKVVK TLKYFDRHGA GPFKTHILLD TERHIFVQWK KHSHPFVTNK
LFSMKDDNYI PREIDQVAGD SGTAIVISFG QHFRPFPINV FIRRAINVKN AIERLFLRSP
ETKVIIKTEN IREINEHVEI FSDFHGSIQN LIIRDIFRDL NVGIIDAWDM TVAYRSEDVH
PPESVIESQI GMFLNYIC
