NXPE3_HUMAN
ID NXPE3_HUMAN Reviewed; 559 AA.
AC Q969Y0; A8K0X4; D3DN53; Q7Z2S8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=NXPE family member 3;
DE AltName: Full=Protein FAM55C;
DE Flags: Precursor;
GN Name=NXPE3; Synonyms=FAM55C; ORFNames=MSTP115, UNQ5791/PRO19596;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala, and Glial tumor;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 241-559.
RC TISSUE=Heart;
RA Zhao B., Zhang Q., Zheng W.Y., Xu H.S., Liu B.H., Lu H., Gong Q.,
RA Tong Y.K., Liu B., Wang X.Y., Liu Y.Q., Sheng H., Qin B.M., Hui R.T.;
RT "Homo sapiens normal heart mRNA MST115.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q969Y0; P00387: CYB5R3; NbExp=3; IntAct=EBI-17973370, EBI-1046040;
CC Q969Y0; P60508: ERVFRD-1; NbExp=3; IntAct=EBI-17973370, EBI-17973325;
CC Q969Y0; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-17973370, EBI-18304435;
CC Q969Y0; Q6IN84: MRM1; NbExp=3; IntAct=EBI-17973370, EBI-5454865;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NXPE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ13637.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY358207; AAQ88574.1; -; mRNA.
DR EMBL; AK054664; BAB70787.1; -; mRNA.
DR EMBL; AK289689; BAF82378.1; -; mRNA.
DR EMBL; CH471052; EAW79774.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79775.1; -; Genomic_DNA.
DR EMBL; BC009431; AAH09431.1; -; mRNA.
DR EMBL; AF173890; AAQ13637.1; ALT_FRAME; mRNA.
DR CCDS; CCDS2945.1; -.
DR RefSeq; NP_001127928.1; NM_001134456.1.
DR RefSeq; NP_659474.1; NM_145037.2.
DR AlphaFoldDB; Q969Y0; -.
DR BioGRID; 124878; 38.
DR IntAct; Q969Y0; 11.
DR STRING; 9606.ENSP00000396421; -.
DR GlyGen; Q969Y0; 3 sites.
DR iPTMnet; Q969Y0; -.
DR PhosphoSitePlus; Q969Y0; -.
DR BioMuta; NXPE3; -.
DR DMDM; 74731068; -.
DR EPD; Q969Y0; -.
DR MassIVE; Q969Y0; -.
DR MaxQB; Q969Y0; -.
DR PaxDb; Q969Y0; -.
DR PeptideAtlas; Q969Y0; -.
DR PRIDE; Q969Y0; -.
DR ProteomicsDB; 75876; -.
DR Antibodypedia; 51258; 45 antibodies from 11 providers.
DR DNASU; 91775; -.
DR Ensembl; ENST00000273347.10; ENSP00000273347.5; ENSG00000144815.17.
DR Ensembl; ENST00000477909.5; ENSP00000418369.1; ENSG00000144815.17.
DR Ensembl; ENST00000491511.6; ENSP00000417485.1; ENSG00000144815.17.
DR GeneID; 91775; -.
DR KEGG; hsa:91775; -.
DR MANE-Select; ENST00000273347.10; ENSP00000273347.5; NM_145037.4; NP_659474.1.
DR UCSC; uc003dvn.4; human.
DR CTD; 91775; -.
DR GeneCards; NXPE3; -.
DR HGNC; HGNC:28238; NXPE3.
DR HPA; ENSG00000144815; Tissue enhanced (skeletal muscle, tongue).
DR neXtProt; NX_Q969Y0; -.
DR OpenTargets; ENSG00000144815; -.
DR PharmGKB; PA134977295; -.
DR VEuPathDB; HostDB:ENSG00000144815; -.
DR eggNOG; ENOG502QUD6; Eukaryota.
DR GeneTree; ENSGT00950000182866; -.
DR HOGENOM; CLU_031119_2_0_1; -.
DR InParanoid; Q969Y0; -.
DR OMA; VHFVDAW; -.
DR OrthoDB; 389418at2759; -.
DR PhylomeDB; Q969Y0; -.
DR TreeFam; TF329555; -.
DR PathwayCommons; Q969Y0; -.
DR SignaLink; Q969Y0; -.
DR BioGRID-ORCS; 91775; 18 hits in 1073 CRISPR screens.
DR ChiTaRS; NXPE3; human.
DR GenomeRNAi; 91775; -.
DR Pharos; Q969Y0; Tdark.
DR PRO; PR:Q969Y0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q969Y0; protein.
DR Bgee; ENSG00000144815; Expressed in buccal mucosa cell and 159 other tissues.
DR ExpressionAtlas; Q969Y0; baseline and differential.
DR Genevisible; Q969Y0; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR026845; NXPH/NXPE.
DR Pfam; PF06312; Neurexophilin; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..559
FT /note="NXPE family member 3"
FT /id="PRO_0000297594"
FT CARBOHYD 237
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 292
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 507
FT /note="T -> I (in dbSNP:rs3796277)"
FT /id="VAR_049024"
SQ SEQUENCE 559 AA; 63800 MW; 56264FEEBFBCF358 CRC64;
MWTNFFKLRL FCCLLAVLMV VVLVINVTQV EYLDHETVSA TFIDSSGQFV SSQVTGISRN
PYCGYDQQTL SSQERMEEDS LLAALHRQVP DVGPVPFVKS TDPSSSYFVI LNSAAFFKVG
SQLEVLVHVQ DFQRKPKKYG GDYLQARIHS LKLQAGAVGR VVDYQNGFYK VFFTLLWPGK
VKVSVSLVHP SEGIRVLQRL QEDKPDRVYF KSLFRSGRIS ETTECNVCLP GNLPLCNFTD
LYTGEPWFCF KPKKLPCSSR ITHFKGGYLK GLLTAAESAF FQSGVNIKMP VNSSGPDWVT
VIPRRIKETN SLELSQGSGT FPSGYYYKDQ WRPRKFKMRQ FNDPDNITEC LQRKVVHLFG
DSTIRQWFEY LTTFVPDLVE FNLGSPKNVG PFLAVDQKHN ILLKYRCHGP PIRFTTVFSN
ELHYVANELN GIVGGKNTVV AIAVWSHFST FPLEVYIRRL RNIRRAVVRL LDRSPKTVVV
IRTANAQELG PEVSLFNSDW YNFQLDTILR RMFSGVGVYL VDAWEMTLAH YLPHKLHPDE
VIVKNQLDMF LSFVCPLET
