NXPE4_HUMAN
ID NXPE4_HUMAN Reviewed; 544 AA.
AC Q6UWF7; Q6QDB4; Q9NXP5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=NXPE family member 4;
DE AltName: Full=Protein FAM55D;
DE Flags: Precursor;
GN Name=NXPE4; Synonyms=C11orf33, FAM55D; ORFNames=UNQ3018/PRO9799;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANTS HIS-398 AND VAL-451.
RC TISSUE=Colon;
RX PubMed=15375555;
RA Solmi R., De Sanctis P., Zucchini C., Ugolini G., Rosati G.,
RA Del Governatore M., Coppola D., Yeatman T.J., Lenzi L., Caira A.,
RA Zanotti S., Taffurelli M., Carinci P., Valvassori L., Strippoli P.;
RT "Search for epithelial-specific mRNAs in peripheral blood of patients with
RT colon cancer by RT-PCR.";
RL Int. J. Oncol. 25:1049-1056(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWF7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWF7-2; Sequence=VSP_014701;
CC -!- SIMILARITY: Belongs to the NXPE family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90965.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY547307; AAS55888.1; -; mRNA.
DR EMBL; AY358805; AAQ89165.1; -; mRNA.
DR EMBL; AK000134; BAA90965.1; ALT_FRAME; mRNA.
DR CCDS; CCDS41718.1; -. [Q6UWF7-1]
DR CCDS; CCDS44737.1; -. [Q6UWF7-2]
DR RefSeq; NP_001071107.1; NM_001077639.1. [Q6UWF7-1]
DR RefSeq; NP_060148.2; NM_017678.2. [Q6UWF7-2]
DR RefSeq; XP_011541183.1; XM_011542881.2. [Q6UWF7-1]
DR AlphaFoldDB; Q6UWF7; -.
DR BioGRID; 120181; 2.
DR IntAct; Q6UWF7; 1.
DR STRING; 9606.ENSP00000364627; -.
DR GlyGen; Q6UWF7; 7 sites.
DR iPTMnet; Q6UWF7; -.
DR PhosphoSitePlus; Q6UWF7; -.
DR BioMuta; NXPE4; -.
DR DMDM; 71153004; -.
DR MassIVE; Q6UWF7; -.
DR PaxDb; Q6UWF7; -.
DR PeptideAtlas; Q6UWF7; -.
DR PRIDE; Q6UWF7; -.
DR ProteomicsDB; 67475; -. [Q6UWF7-1]
DR ProteomicsDB; 67476; -. [Q6UWF7-2]
DR Antibodypedia; 9003; 82 antibodies from 18 providers.
DR DNASU; 54827; -.
DR Ensembl; ENST00000375478.4; ENSP00000364627.3; ENSG00000137634.10. [Q6UWF7-1]
DR Ensembl; ENST00000424261.6; ENSP00000401503.2; ENSG00000137634.10. [Q6UWF7-2]
DR GeneID; 54827; -.
DR KEGG; hsa:54827; -.
DR MANE-Select; ENST00000375478.4; ENSP00000364627.3; NM_001077639.2; NP_001071107.1.
DR UCSC; uc001ppc.4; human. [Q6UWF7-1]
DR CTD; 54827; -.
DR DisGeNET; 54827; -.
DR GeneCards; NXPE4; -.
DR HGNC; HGNC:23117; NXPE4.
DR HPA; ENSG00000137634; Group enriched (intestine, salivary gland).
DR MIM; 618133; gene.
DR neXtProt; NX_Q6UWF7; -.
DR OpenTargets; ENSG00000137634; -.
DR PharmGKB; PA134871713; -.
DR VEuPathDB; HostDB:ENSG00000137634; -.
DR eggNOG; ENOG502QW5F; Eukaryota.
DR GeneTree; ENSGT00950000182866; -.
DR HOGENOM; CLU_031119_1_0_1; -.
DR InParanoid; Q6UWF7; -.
DR OMA; LHHWNFI; -.
DR OrthoDB; 587284at2759; -.
DR PhylomeDB; Q6UWF7; -.
DR TreeFam; TF329555; -.
DR PathwayCommons; Q6UWF7; -.
DR SignaLink; Q6UWF7; -.
DR BioGRID-ORCS; 54827; 6 hits in 1063 CRISPR screens.
DR GenomeRNAi; 54827; -.
DR Pharos; Q6UWF7; Tdark.
DR PRO; PR:Q6UWF7; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UWF7; protein.
DR Bgee; ENSG00000137634; Expressed in rectum and 52 other tissues.
DR Genevisible; Q6UWF7; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR026845; NXPH/NXPE.
DR Pfam; PF06312; Neurexophilin; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..544
FT /note="NXPE family member 4"
FT /id="PRO_0000019553"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..284
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15375555"
FT /id="VSP_014701"
FT VARIANT 398
FT /note="Y -> H (in dbSNP:rs550897)"
FT /evidence="ECO:0000269|PubMed:15375555"
FT /id="VAR_049025"
FT VARIANT 451
FT /note="A -> V (in dbSNP:rs10891705)"
FT /evidence="ECO:0000269|PubMed:15375555"
FT /id="VAR_049026"
FT CONFLICT 293
FT /note="V -> A (in Ref. 3; BAA90965)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 544 AA; 62263 MW; FF41C00DF8E8DB57 CRC64;
MKISMINYKS LLALLFILAS WIIFTVFQNS TKVWSALNLS ISLHYWNNST KSLFPKTPLI
SLKPLTETEL RIKEIIEKLD QQIPPRPFTH VNTTTSATHS TATILNPRDT YCRGDQLHIL
LEVRDHLGRR KQYGGDFLRA RMSSPALMAG ASGKVTDFNN GTYLVSFTLF WEGQVSLSLL
LIHPSEGVSA LWSARNQGYD RVIFTGQFVN GTSQVHSECG LILNTNAELC QYLDNRDQEG
FYCVRPQHMP CAALTHMYSK NKKVSYLSKQ EKSLFERSNV GVEIMEKFNT ISVSKCNKET
VAMKEKCKFG MTSTIPSGHV WRNTWNPVSC SLATVKMKEC LRGKLIYLMG DSTIRQWMEY
FKASINTLKS VDLHESGKLQ HQLAVDLDRN INIQWQKYCY PLIGSMTYSV KEMEYLTRAI
DRTGGEKNTV IVISLGQHFR PFPIDVFIRR ALNVHKAIQH LLLRSPDTMV IIKTENIREM
YNDAERFSDF HGYIQYLIIK DIFQDLSVSI IDAWDITIAY GTNNVHPPQH VVGNQINILL
NYIC
