NXPE4_MOUSE
ID NXPE4_MOUSE Reviewed; 543 AA.
AC Q52KP5; Q0VGS9; Q8BKY4;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=NXPE family member 4;
DE AltName: Full=Protein FAM55D;
DE Flags: Precursor;
GN Name=Nxpe4; Synonyms=Fam55d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryonic brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q52KP5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q52KP5-2; Sequence=VSP_014702;
CC -!- SIMILARITY: Belongs to the NXPE family. {ECO:0000305}.
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DR EMBL; AK048132; BAC33253.1; -; mRNA.
DR EMBL; BC085195; AAH85195.1; -; mRNA.
DR EMBL; BC094249; AAH94249.1; -; mRNA.
DR CCDS; CCDS23152.1; -. [Q52KP5-1]
DR RefSeq; NP_766509.2; NM_172921.3. [Q52KP5-1]
DR RefSeq; XP_006510388.1; XM_006510325.2. [Q52KP5-1]
DR RefSeq; XP_017168864.1; XM_017313375.1. [Q52KP5-1]
DR RefSeq; XP_017168865.1; XM_017313376.1. [Q52KP5-1]
DR RefSeq; XP_017168866.1; XM_017313377.1. [Q52KP5-1]
DR RefSeq; XP_017168867.1; XM_017313378.1. [Q52KP5-1]
DR RefSeq; XP_017168868.1; XM_017313379.1. [Q52KP5-1]
DR RefSeq; XP_017168869.1; XM_017313380.1. [Q52KP5-1]
DR RefSeq; XP_017168870.1; XM_017313381.1.
DR RefSeq; XP_017168871.1; XM_017313382.1. [Q52KP5-1]
DR RefSeq; XP_017168872.1; XM_017313383.1.
DR RefSeq; XP_017168873.1; XM_017313384.1. [Q52KP5-1]
DR RefSeq; XP_017168874.1; XM_017313385.1. [Q52KP5-1]
DR AlphaFoldDB; Q52KP5; -.
DR BioGRID; 232692; 3.
DR STRING; 10090.ENSMUSP00000091375; -.
DR GlyGen; Q52KP5; 3 sites.
DR iPTMnet; Q52KP5; -.
DR PhosphoSitePlus; Q52KP5; -.
DR MaxQB; Q52KP5; -.
DR PaxDb; Q52KP5; -.
DR PRIDE; Q52KP5; -.
DR ProteomicsDB; 293910; -. [Q52KP5-1]
DR ProteomicsDB; 293911; -. [Q52KP5-2]
DR Antibodypedia; 9003; 82 antibodies from 18 providers.
DR DNASU; 244853; -.
DR Ensembl; ENSMUST00000093853; ENSMUSP00000091375; ENSMUSG00000044229. [Q52KP5-1]
DR Ensembl; ENSMUST00000215780; ENSMUSP00000149741; ENSMUSG00000044229. [Q52KP5-1]
DR Ensembl; ENSMUST00000216998; ENSMUSP00000149644; ENSMUSG00000044229. [Q52KP5-2]
DR GeneID; 244853; -.
DR KEGG; mmu:244853; -.
DR UCSC; uc009phu.2; mouse. [Q52KP5-1]
DR UCSC; uc009phv.2; mouse. [Q52KP5-2]
DR CTD; 54827; -.
DR MGI; MGI:1924792; Nxpe4.
DR VEuPathDB; HostDB:ENSMUSG00000044229; -.
DR eggNOG; ENOG502QW5F; Eukaryota.
DR GeneTree; ENSGT00950000182866; -.
DR HOGENOM; CLU_031119_0_0_1; -.
DR InParanoid; Q52KP5; -.
DR OMA; DTHINIQ; -.
DR PhylomeDB; Q52KP5; -.
DR TreeFam; TF329555; -.
DR BioGRID-ORCS; 244853; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Nxpe4; mouse.
DR PRO; PR:Q52KP5; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q52KP5; protein.
DR Bgee; ENSMUSG00000044229; Expressed in prostate gland and 174 other tissues.
DR Genevisible; Q52KP5; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR026845; NXPH/NXPE.
DR Pfam; PF06312; Neurexophilin; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..543
FT /note="NXPE family member 4"
FT /id="PRO_0000019554"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 223
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 366..543
FT /note="TLRSVDLHESGKLQHQLAVDLDEKISIQWQKHGYPLIGSLVYSVKEIENIAR
FT IIDRTGGEKNTVIVISLGQHFRPFPIDLFIRRALNVHKALQRLLLRSPDTVVVLKTENT
FT RELNSDVERFSDFHGYTQYLALKDIFQDLNVGVIDAWDMTVAYGINNVHPPEDVVRSQI
FT NIFLNYIC -> SMSQYKLFKALSETMFLFQGRKKKYRRCLFFTIVFKHKPRALFTKCY
FT YHSLEQCSLPLVLV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_014702"
SQ SEQUENCE 543 AA; 61551 MW; BC73FC7C5C9CCF3A CRC64;
MKTLASRKSL WMLLFIVIFW VSFTVFRNPV KLRTMFKLPV SFNRWNLVMG PSCPAVPLNL
PVSPKETELR IREVLEKLDK QIPPRPFTHL NYTTSATHST ATILNPRDTH CVGDQLDILV
EARDHLGNRK GYGGDFMRAR MFSPALKAGA SGKVTDFNNG TYLVSFTLFW EGTVSLSILL
MHPSEGVSAL WRSRKQGYDR IIFSGQFVSG ASQVHTECAL VLNSSVELCQ YLDAQDQEAF
YCVKPPNVPC AALTYMQSKN KDVSYLSQQE RSLFERSNIA VEIMEKSNAI SVSKCNTDTA
PVKEKCKLGM VSAIPSGHVW KNAWTPASCS LAPIKMKDCL RGKFIYLMGD STIRQWMEYF
KSKVNTLRSV DLHESGKLQH QLAVDLDEKI SIQWQKHGYP LIGSLVYSVK EIENIARIID
RTGGEKNTVI VISLGQHFRP FPIDLFIRRA LNVHKALQRL LLRSPDTVVV LKTENTRELN
SDVERFSDFH GYTQYLALKD IFQDLNVGVI DAWDMTVAYG INNVHPPEDV VRSQINIFLN
YIC
