ID   NXPH1_BOVIN             Reviewed;         271 AA.
AC   Q5E9M6; Q08DQ7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Neurexophilin-1;
DE   Flags: Precursor;
GN   Name=NXPH1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal medulla;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides.
CC       Ligand for alpha-neurexins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: May be proteolytically processed at the boundary between the N-
CC       terminal non-conserved and the central conserved domain in neuron-like
CC       cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR   EMBL; BT020894; AAX08911.1; -; mRNA.
DR   EMBL; BC123618; AAI23619.1; -; mRNA.
DR   RefSeq; NP_001029934.1; NM_001034762.1.
DR   AlphaFoldDB; Q5E9M6; -.
DR   SMR; Q5E9M6; -.
DR   STRING; 9913.ENSBTAP00000009085; -.
DR   PaxDb; Q5E9M6; -.
DR   PRIDE; Q5E9M6; -.
DR   GeneID; 614571; -.
DR   KEGG; bta:614571; -.
DR   CTD; 30010; -.
DR   eggNOG; ENOG502QQUX; Eukaryota.
DR   InParanoid; Q5E9M6; -.
DR   OrthoDB; 971662at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..271
FT                   /note="Neurexophilin-1"
FT                   /id="PRO_0000250711"
FT   REGION          22..97
FT                   /note="II"
FT                   /evidence="ECO:0000250"
FT   REGION          98..176
FT                   /note="III"
FT                   /evidence="ECO:0000250"
FT   REGION          177..185
FT                   /note="IV (linker domain)"
FT                   /evidence="ECO:0000250"
FT   REGION          186..271
FT                   /note="V (Cys-rich)"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  31018 MW;  59BF7C3153DAC1D9 CRC64;
     MQAACWYVLL LLQPTVYLVT CANLTNGGKS ELLKSGGSKS TLKHIWTESS KDLSISRLLS
     QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG
     WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ
     QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI
     YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G