NXPH1_HUMAN
ID NXPH1_HUMAN Reviewed; 271 AA.
AC P58417; Q8NB31;
DT 05-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Neurexophilin-1;
DE Flags: Precursor;
GN Name=NXPH1; Synonyms=NPH1; ORFNames=Nbla00697;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RX PubMed=12880961; DOI=10.1016/s0304-3835(03)00085-5;
RA Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S.,
RA Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S.,
RA Hirato J., Nakagawara A.;
RT "Neuroblastoma oligo-capping cDNA project: toward the understanding of the
RT genesis and biology of neuroblastoma.";
RL Cancer Lett. 197:63-68(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be signaling molecules that resemble neuropeptides and
CC that act by binding to alpha-neurexins and possibly other receptors.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR EMBL; AB047362; BAB69044.1; -; mRNA.
DR EMBL; AK091655; BAC03713.1; -; mRNA.
DR EMBL; AC004457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC004861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047505; AAH47505.1; -; mRNA.
DR CCDS; CCDS47540.1; -.
DR RefSeq; NP_689958.1; NM_152745.2.
DR AlphaFoldDB; P58417; -.
DR SMR; P58417; -.
DR BioGRID; 119028; 27.
DR STRING; 9606.ENSP00000384551; -.
DR GlyGen; P58417; 7 sites, 1 O-linked glycan (1 site).
DR iPTMnet; P58417; -.
DR PhosphoSitePlus; P58417; -.
DR BioMuta; NXPH1; -.
DR DMDM; 17433155; -.
DR MassIVE; P58417; -.
DR PaxDb; P58417; -.
DR PeptideAtlas; P58417; -.
DR PRIDE; P58417; -.
DR ProteomicsDB; 57073; -.
DR Antibodypedia; 43889; 257 antibodies from 33 providers.
DR DNASU; 30010; -.
DR Ensembl; ENST00000405863.6; ENSP00000384551.1; ENSG00000122584.13.
DR GeneID; 30010; -.
DR KEGG; hsa:30010; -.
DR MANE-Select; ENST00000405863.6; ENSP00000384551.1; NM_152745.3; NP_689958.1.
DR CTD; 30010; -.
DR DisGeNET; 30010; -.
DR GeneCards; NXPH1; -.
DR HGNC; HGNC:20693; NXPH1.
DR HPA; ENSG00000122584; Group enriched (adrenal gland, brain).
DR MIM; 604639; gene.
DR neXtProt; NX_P58417; -.
DR OpenTargets; ENSG00000122584; -.
DR PharmGKB; PA134961263; -.
DR VEuPathDB; HostDB:ENSG00000122584; -.
DR eggNOG; ENOG502QQUX; Eukaryota.
DR GeneTree; ENSGT00950000182883; -.
DR InParanoid; P58417; -.
DR OMA; HYNTPEP; -.
DR OrthoDB; 971662at2759; -.
DR PhylomeDB; P58417; -.
DR TreeFam; TF333047; -.
DR PathwayCommons; P58417; -.
DR SignaLink; P58417; -.
DR SIGNOR; P58417; -.
DR BioGRID-ORCS; 30010; 10 hits in 1065 CRISPR screens.
DR ChiTaRS; NXPH1; human.
DR GeneWiki; NXPH1; -.
DR GenomeRNAi; 30010; -.
DR Pharos; P58417; Tbio.
DR PRO; PR:P58417; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P58417; protein.
DR Bgee; ENSG00000122584; Expressed in right adrenal gland cortex and 80 other tissues.
DR ExpressionAtlas; P58417; baseline and differential.
DR Genevisible; P58417; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR InterPro; IPR010450; Nxph.
DR InterPro; IPR026845; NXPH/NXPE.
DR PANTHER; PTHR17103; PTHR17103; 1.
DR Pfam; PF06312; Neurexophilin; 1.
DR PIRSF; PIRSF038019; Neurexophilin; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..271
FT /note="Neurexophilin-1"
FT /id="PRO_0000020059"
FT REGION 22..97
FT /note="II"
FT REGION 98..176
FT /note="III"
FT REGION 177..185
FT /note="IV (linker domain)"
FT REGION 186..271
FT /note="V (Cys-rich)"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 146
FT /note="N -> S (in Ref. 2; BAC03713)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31082 MW; 140C6C7DE1126B27 CRC64;
MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS
QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG
WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ
QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI
YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G
