NXPH1_MOUSE
ID NXPH1_MOUSE Reviewed; 271 AA.
AC Q61200; A6H6P7; Q8BHJ2; Q8BLP4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Neurexophilin-1;
DE Flags: Precursor;
GN Name=Nxph1; Synonyms=Nph1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex, Head, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-271.
RC STRAIN=129/Sv;
RX PubMed=8699246; DOI=10.1523/jneurosci.16-14-04360.1996;
RA Petrenko A.G., Ullrich B., Missler M., Krasnoperov V., Rosahl T.W.,
RA Suedhof T.C.;
RT "Structure and evolution of neurexophilin.";
RL J. Neurosci. 16:4360-4369(1996).
CC -!- FUNCTION: May be signaling molecules that resemble neuropeptides.
CC Ligand for alpha-neurexins.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain, only in a scattered subpopulation of neurons
CC that probably represent inhibitory interneurons.
CC -!- PTM: May be proteolytically processed at the boundary between the N-
CC terminal non-conserved and the central conserved domain in neuron-like
CC cells.
CC -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK043942; BAC31708.1; -; mRNA.
DR EMBL; AK047847; BAC33174.1; -; mRNA.
DR EMBL; AK083014; BAC38730.1; -; mRNA.
DR EMBL; BC145953; AAI45954.1; -; mRNA.
DR EMBL; BC145955; AAI45956.1; -; mRNA.
DR EMBL; U56651; AAB18764.1; -; Genomic_DNA.
DR CCDS; CCDS39426.1; -.
DR RefSeq; NP_032777.3; NM_008751.5.
DR RefSeq; XP_006505073.1; XM_006505010.3.
DR AlphaFoldDB; Q61200; -.
DR SMR; Q61200; -.
DR STRING; 10090.ENSMUSP00000125274; -.
DR GlyConnect; 2542; 3 N-Linked glycans (3 sites).
DR GlyGen; Q61200; 6 sites, 3 N-linked glycans (3 sites).
DR PhosphoSitePlus; Q61200; -.
DR MaxQB; Q61200; -.
DR PaxDb; Q61200; -.
DR PRIDE; Q61200; -.
DR ProteomicsDB; 293912; -.
DR Antibodypedia; 43889; 257 antibodies from 33 providers.
DR DNASU; 18231; -.
DR Ensembl; ENSMUST00000060369; ENSMUSP00000060926; ENSMUSG00000046178.
DR Ensembl; ENSMUST00000160300; ENSMUSP00000125274; ENSMUSG00000046178.
DR GeneID; 18231; -.
DR KEGG; mmu:18231; -.
DR UCSC; uc009ayb.1; mouse.
DR CTD; 30010; -.
DR MGI; MGI:107492; Nxph1.
DR VEuPathDB; HostDB:ENSMUSG00000046178; -.
DR eggNOG; ENOG502QQUX; Eukaryota.
DR GeneTree; ENSGT00950000182883; -.
DR HOGENOM; CLU_067114_1_0_1; -.
DR InParanoid; Q61200; -.
DR OMA; HYNTPEP; -.
DR OrthoDB; 971662at2759; -.
DR PhylomeDB; Q61200; -.
DR TreeFam; TF333047; -.
DR BioGRID-ORCS; 18231; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Nxph1; mouse.
DR PRO; PR:Q61200; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q61200; protein.
DR Bgee; ENSMUSG00000046178; Expressed in lateral septal nucleus and 119 other tissues.
DR Genevisible; Q61200; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR InterPro; IPR010450; Nxph.
DR InterPro; IPR026845; NXPH/NXPE.
DR PANTHER; PTHR17103; PTHR17103; 1.
DR Pfam; PF06312; Neurexophilin; 1.
DR PIRSF; PIRSF038019; Neurexophilin; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..271
FT /note="Neurexophilin-1"
FT /id="PRO_0000020060"
FT REGION 22..97
FT /note="II"
FT REGION 98..176
FT /note="III"
FT REGION 177..185
FT /note="IV (linker domain)"
FT REGION 186..271
FT /note="V (Cys-rich)"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 148
FT /note="T -> N (in Ref. 1; BAC31708)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 31048 MW; 1409A31DE111E647 CRC64;
MQAACWYVLL LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS
QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG
WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ
QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI
YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G
