ID   NXPH1_PONAB             Reviewed;         271 AA.
AC   Q5R530;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Neurexophilin-1;
DE   Flags: Precursor;
GN   Name=NXPH1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides and
CC       that act by binding to alpha-neurexins and possibly other receptors.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR861048; CAH93136.1; -; mRNA.
DR   RefSeq; NP_001128993.1; NM_001135521.1.
DR   AlphaFoldDB; Q5R530; -.
DR   SMR; Q5R530; -.
DR   STRING; 9601.ENSPPYP00000019932; -.
DR   GeneID; 100190833; -.
DR   KEGG; pon:100190833; -.
DR   CTD; 30010; -.
DR   eggNOG; ENOG502QQUX; Eukaryota.
DR   InParanoid; Q5R530; -.
DR   OrthoDB; 971662at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..271
FT                   /note="Neurexophilin-1"
FT                   /id="PRO_0000250712"
FT   REGION          22..97
FT                   /note="II"
FT                   /evidence="ECO:0000250"
FT   REGION          98..176
FT                   /note="III"
FT                   /evidence="ECO:0000250"
FT   REGION          177..185
FT                   /note="IV (linker domain)"
FT                   /evidence="ECO:0000250"
FT   REGION          186..271
FT                   /note="V (Cys-rich)"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   271 AA;  31062 MW;  F8D9A317D211E640 CRC64;
     MQAACWYVLL LLQPTIYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS
     QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG
     WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ
     QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI
     YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G