NXPH2_MOUSE
ID NXPH2_MOUSE Reviewed; 261 AA.
AC Q61199; Q8BIN8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Neurexophilin-2;
DE Flags: Precursor;
GN Name=Nxph2; Synonyms=Nph2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-261.
RX PubMed=8699246; DOI=10.1523/jneurosci.16-14-04360.1996;
RA Petrenko A.G., Ullrich B., Missler M., Krasnoperov V., Rosahl T.W.,
RA Suedhof T.C.;
RT "Structure and evolution of neurexophilin.";
RL J. Neurosci. 16:4360-4369(1996).
CC -!- FUNCTION: May be signaling molecules that resemble neuropeptides and
CC that act by binding to alpha-neurexins and possibly other receptors.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- PTM: May be proteolytically processed at the boundary between the N-
CC terminal non-conserved and the central conserved domain in neuron-like
CC cells. {ECO:0000250}.
CC -!- MISCELLANEOUS: Rodents express at detectable levels only
CC neurexophilins-1, -3, and -4.
CC -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR EMBL; AK038402; BAC29985.1; -; mRNA.
DR EMBL; U56650; AAB18763.1; -; Genomic_DNA.
DR CCDS; CCDS15729.1; -.
DR RefSeq; NP_032778.1; NM_008752.2.
DR AlphaFoldDB; Q61199; -.
DR SMR; Q61199; -.
DR STRING; 10090.ENSMUSP00000100009; -.
DR GlyGen; Q61199; 4 sites.
DR PhosphoSitePlus; Q61199; -.
DR MaxQB; Q61199; -.
DR PaxDb; Q61199; -.
DR PRIDE; Q61199; -.
DR Antibodypedia; 51377; 105 antibodies from 23 providers.
DR DNASU; 18232; -.
DR Ensembl; ENSMUST00000102945; ENSMUSP00000100009; ENSMUSG00000069132.
DR GeneID; 18232; -.
DR KEGG; mmu:18232; -.
DR UCSC; uc008iog.1; mouse.
DR CTD; 11249; -.
DR MGI; MGI:107491; Nxph2.
DR VEuPathDB; HostDB:ENSMUSG00000069132; -.
DR eggNOG; ENOG502QUPW; Eukaryota.
DR GeneTree; ENSGT00950000182883; -.
DR HOGENOM; CLU_067114_2_1_1; -.
DR InParanoid; Q61199; -.
DR OMA; WDWLANV; -.
DR OrthoDB; 971662at2759; -.
DR PhylomeDB; Q61199; -.
DR TreeFam; TF333047; -.
DR BioGRID-ORCS; 18232; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q61199; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q61199; protein.
DR Bgee; ENSMUSG00000069132; Expressed in cortical plate and 18 other tissues.
DR ExpressionAtlas; Q61199; baseline and differential.
DR Genevisible; Q61199; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR InterPro; IPR010450; Nxph.
DR InterPro; IPR026845; NXPH/NXPE.
DR PANTHER; PTHR17103; PTHR17103; 1.
DR Pfam; PF06312; Neurexophilin; 1.
DR PIRSF; PIRSF038019; Neurexophilin; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..261
FT /note="Neurexophilin-2"
FT /id="PRO_0000020064"
FT REGION 23..87
FT /note="II"
FT REGION 88..166
FT /note="III"
FT REGION 167..175
FT /note="IV (linker domain)"
FT REGION 176..261
FT /note="V (Cys-rich)"
FT CARBOHYD 83
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 146
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 152
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 255
FT /note="T -> R (in Ref. 2; AAB18763)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 29975 MW; 03F697C3E2284A12 CRC64;
MSLRPLPLLV VPGLLQLLFC DSEEVIHNTE SVDWEDRTVP ETLVGNLFHS RITSPLRLFV
KQPPDPKPSY ADNTKNFWDW LANITEIQEQ LARTKRRPIV KTGKFKKMFG WGDFHSNIKT
VKLNLLITGK IVDHGNGTFS VYFRHNSTGL GNVSVSLVPP SKVVEFEISP QSTLETKESK
SFNCHIEYEK TDRAKKTALC NFDPSKICYQ EQTQSHVSWL CSKPFKVICI HIIFYSVDYK
LVQKVCPDYN YHSETPYLSF G
