NXPH3_HUMAN
ID NXPH3_HUMAN Reviewed; 252 AA.
AC O95157; Q8NDC3; Q8TBF6; Q9ULR1;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2002, sequence version 3.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Neurexophilin-3;
DE Flags: Precursor;
GN Name=NXPH3; Synonyms=KIAA1159, NPH3; ORFNames=UNQ687/PRO1327;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-252.
RC TISSUE=Brain;
RX PubMed=10574461; DOI=10.1093/dnares/6.5.329;
RA Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.;
RT "Characterization of cDNA clones selected by the GeneMark analysis from
RT size-fractionated cDNA libraries from human brain.";
RL DNA Res. 6:329-336(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 80-252.
RX PubMed=9570794; DOI=10.1523/jneurosci.18-10-03630.1998;
RA Missler M., Suedhof T.C.;
RT "Neurexophilins form a conserved family of neuropeptide-like
RT glycoproteins.";
RL J. Neurosci. 18:3630-3638(1998).
RN [7]
RP PROTEIN SEQUENCE OF 23-37.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: May be signaling molecules that resemble neuropeptides.
CC Ligand for alpha-neurexins (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highest level in brain.
CC -!- PTM: May be proteolytically processed at the boundary between the N-
CC terminal non-conserved and the central conserved domain in neuron-like
CC cells. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR EMBL; AY358526; AAQ88890.1; -; mRNA.
DR EMBL; AL834282; CAD38956.2; -; mRNA.
DR EMBL; CH471109; EAW94676.1; -; Genomic_DNA.
DR EMBL; BC022541; AAH22541.1; -; mRNA.
DR EMBL; AB032985; BAA86473.1; -; mRNA.
DR EMBL; AF043468; AAD02281.1; -; mRNA.
DR CCDS; CCDS11550.1; -.
DR RefSeq; NP_009156.2; NM_007225.2.
DR AlphaFoldDB; O95157; -.
DR SMR; O95157; -.
DR BioGRID; 116409; 86.
DR IntAct; O95157; 11.
DR MINT; O95157; -.
DR STRING; 9606.ENSP00000329295; -.
DR GlyGen; O95157; 4 sites.
DR iPTMnet; O95157; -.
DR PhosphoSitePlus; O95157; -.
DR BioMuta; NXPH3; -.
DR MassIVE; O95157; -.
DR PaxDb; O95157; -.
DR PeptideAtlas; O95157; -.
DR PRIDE; O95157; -.
DR Antibodypedia; 30401; 178 antibodies from 25 providers.
DR DNASU; 11248; -.
DR Ensembl; ENST00000328741.6; ENSP00000329295.6; ENSG00000182575.8.
DR GeneID; 11248; -.
DR KEGG; hsa:11248; -.
DR MANE-Select; ENST00000328741.6; ENSP00000329295.6; NM_007225.4; NP_009156.2.
DR UCSC; uc002ipa.4; human.
DR CTD; 11248; -.
DR DisGeNET; 11248; -.
DR GeneCards; NXPH3; -.
DR HGNC; HGNC:8077; NXPH3.
DR HPA; ENSG00000182575; Low tissue specificity.
DR MIM; 604636; gene.
DR neXtProt; NX_O95157; -.
DR OpenTargets; ENSG00000182575; -.
DR PharmGKB; PA31865; -.
DR VEuPathDB; HostDB:ENSG00000182575; -.
DR eggNOG; ENOG502QSZ5; Eukaryota.
DR GeneTree; ENSGT00950000182883; -.
DR HOGENOM; CLU_067114_2_0_1; -.
DR InParanoid; O95157; -.
DR OMA; PSKTCYH; -.
DR OrthoDB; 1098941at2759; -.
DR PhylomeDB; O95157; -.
DR TreeFam; TF333047; -.
DR PathwayCommons; O95157; -.
DR SignaLink; O95157; -.
DR BioGRID-ORCS; 11248; 12 hits in 1072 CRISPR screens.
DR GeneWiki; NXPH3; -.
DR GenomeRNAi; 11248; -.
DR Pharos; O95157; Tdark.
DR PRO; PR:O95157; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; O95157; protein.
DR Bgee; ENSG00000182575; Expressed in cortical plate and 166 other tissues.
DR ExpressionAtlas; O95157; baseline and differential.
DR Genevisible; O95157; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR InterPro; IPR010450; Nxph.
DR InterPro; IPR026845; NXPH/NXPE.
DR PANTHER; PTHR17103; PTHR17103; 1.
DR Pfam; PF06312; Neurexophilin; 1.
DR PIRSF; PIRSF038019; Neurexophilin; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 23..252
FT /note="Neurexophilin-3"
FT /id="PRO_0000020065"
FT REGION 23..75
FT /note="II"
FT REGION 27..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..157
FT /note="III"
FT REGION 158..166
FT /note="IV (linker domain)"
FT REGION 167..252
FT /note="V (Cys-rich)"
FT COMPBIAS 28..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 178
FT /note="E -> G (in Ref. 4; AAH22541)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28127 MW; 74D2B3D5A89D221F CRC64;
MQLTRCCFVF LVQGSLYLVI CGQDDGPPGS EDPERDDHEG QPRPRVPRKR GHISPKSRPM
ANSTLLGLLA PPGEAWGILG QPPNRPNHSP PPSAKVKKIF GWGDFYSNIK TVALNLLVTG
KIVDHGNGTF SVHFQHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE
KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKVVC VYIAFYSTDY RLVQKVCPDY
NYHSDTPYYP SG
