ID   NXPH3_RAT               Reviewed;         252 AA.
AC   Q9Z2N5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Neurexophilin-3;
DE   Flags: Precursor;
GN   Name=Nxph3; Synonyms=Nph3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9570794; DOI=10.1523/jneurosci.18-10-03630.1998;
RA   Missler M., Suedhof T.C.;
RT   "Neurexophilins form a conserved family of neuropeptide-like
RT   glycoproteins.";
RL   J. Neurosci. 18:3630-3638(1998).
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides.
CC       Ligand for alpha-neurexins (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Brain. Detected in several other tissues.
CC   -!- PTM: May be proteolytically processed at the boundary between the N-
CC       terminal non-conserved and the central conserved domain in neuron-like
CC       cells. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF042713; AAD02226.1; -; mRNA.
DR   RefSeq; NP_067711.1; NM_021679.1.
DR   AlphaFoldDB; Q9Z2N5; -.
DR   SMR; Q9Z2N5; -.
DR   STRING; 10116.ENSRNOP00000007133; -.
DR   GlyGen; Q9Z2N5; 4 sites.
DR   PaxDb; Q9Z2N5; -.
DR   GeneID; 59315; -.
DR   KEGG; rno:59315; -.
DR   CTD; 11248; -.
DR   RGD; 620693; Nxph3.
DR   eggNOG; ENOG502QSZ5; Eukaryota.
DR   InParanoid; Q9Z2N5; -.
DR   OrthoDB; 1098941at2759; -.
DR   PhylomeDB; Q9Z2N5; -.
DR   PRO; PR:Q9Z2N5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 1.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..252
FT                   /note="Neurexophilin-3"
FT                   /id="PRO_0000020067"
FT   REGION          23..75
FT                   /note="II"
FT   REGION          27..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          76..157
FT                   /note="III"
FT   REGION          158..166
FT                   /note="IV (linker domain)"
FT   REGION          167..252
FT                   /note="V (Cys-rich)"
FT   COMPBIAS        28..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        127
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   252 AA;  28225 MW;  5FF10603CE66D8BA CRC64;
     MQLTRCCFVF LVQGSLYLVI CGQEDGPPGS EDPEHDDHEG QPRPRVPRKR GHISPKSRPL
     ANSTLLGLLA PPGEVWGILG QPPNRPKQSP LPSTKVKKIF GWGDFYSNIK TVALNLLVTG
     KIVDHGNGTF SVHFRHNATG QGNISISLVP PSKAVEFHQE QQIFIEAKAS KIFNCRMEWE
     KVERGRRTSL CTHDPAKICS RDHAQSSATW SCSQPFKIVC VYIAFYSTDY RLVQKVCPDY
     NYHSDTPYYP SG