NXPH4_HUMAN
ID NXPH4_HUMAN Reviewed; 308 AA.
AC O95158; A8K4I4; Q7Z6L3; Q8N462;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Neurexophilin-4;
DE Flags: Precursor;
GN Name=NXPH4; Synonyms=NPH4; ORFNames=UNQ1928/PRO4403;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 225-308.
RX PubMed=9570794; DOI=10.1523/jneurosci.18-10-03630.1998;
RA Missler M., Suedhof T.C.;
RT "Neurexophilins form a conserved family of neuropeptide-like
RT glycoproteins.";
RL J. Neurosci. 18:3630-3638(1998).
CC -!- FUNCTION: May be signaling molecules that resemble neuropeptides and
CC that act by binding to alpha-neurexins and possibly other receptors.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, spleen, and testis.
CC -!- PTM: May be proteolytically processed at the boundary between the N-
CC terminal non-conserved and the central conserved domain in neuron-like
CC cells. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR EMBL; AY358614; AAQ88977.1; -; mRNA.
DR EMBL; AK290949; BAF83638.1; -; mRNA.
DR EMBL; BC036679; AAH36679.1; -; mRNA.
DR EMBL; BC053581; AAH53581.1; -; mRNA.
DR EMBL; AF043469; AAD02282.1; -; mRNA.
DR CCDS; CCDS8933.1; -.
DR RefSeq; NP_009155.1; NM_007224.3.
DR AlphaFoldDB; O95158; -.
DR SMR; O95158; -.
DR BioGRID; 116408; 69.
DR IntAct; O95158; 1.
DR STRING; 9606.ENSP00000333593; -.
DR GlyGen; O95158; 4 sites.
DR iPTMnet; O95158; -.
DR PhosphoSitePlus; O95158; -.
DR BioMuta; NXPH4; -.
DR MassIVE; O95158; -.
DR MaxQB; O95158; -.
DR PaxDb; O95158; -.
DR PeptideAtlas; O95158; -.
DR PRIDE; O95158; -.
DR ProteomicsDB; 50675; -.
DR Antibodypedia; 28526; 154 antibodies from 25 providers.
DR DNASU; 11247; -.
DR Ensembl; ENST00000349394.6; ENSP00000333593.6; ENSG00000182379.10.
DR GeneID; 11247; -.
DR KEGG; hsa:11247; -.
DR MANE-Select; ENST00000349394.6; ENSP00000333593.6; NM_007224.4; NP_009155.1.
DR UCSC; uc010srf.2; human.
DR CTD; 11247; -.
DR DisGeNET; 11247; -.
DR GeneCards; NXPH4; -.
DR HGNC; HGNC:8078; NXPH4.
DR HPA; ENSG00000182379; Tissue enhanced (brain, skin).
DR MIM; 604637; gene.
DR neXtProt; NX_O95158; -.
DR OpenTargets; ENSG00000182379; -.
DR PharmGKB; PA31866; -.
DR VEuPathDB; HostDB:ENSG00000182379; -.
DR eggNOG; ENOG502QPNQ; Eukaryota.
DR GeneTree; ENSGT00950000182883; -.
DR HOGENOM; CLU_067114_0_0_1; -.
DR InParanoid; O95158; -.
DR OMA; TARAWSW; -.
DR OrthoDB; 1030335at2759; -.
DR PhylomeDB; O95158; -.
DR TreeFam; TF333047; -.
DR PathwayCommons; O95158; -.
DR SignaLink; O95158; -.
DR BioGRID-ORCS; 11247; 15 hits in 1076 CRISPR screens.
DR ChiTaRS; NXPH4; human.
DR GenomeRNAi; 11247; -.
DR Pharos; O95158; Tbio.
DR PRO; PR:O95158; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; O95158; protein.
DR Bgee; ENSG00000182379; Expressed in ganglionic eminence and 103 other tissues.
DR ExpressionAtlas; O95158; baseline and differential.
DR Genevisible; O95158; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
DR InterPro; IPR010450; Nxph.
DR InterPro; IPR026845; NXPH/NXPE.
DR PANTHER; PTHR17103; PTHR17103; 1.
DR Pfam; PF06312; Neurexophilin; 2.
DR PIRSF; PIRSF038019; Neurexophilin; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..308
FT /note="Neurexophilin-4"
FT /id="PRO_0000020068"
FT REGION 24..84
FT /note="II"
FT REGION 40..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..163
FT /note="III"
FT REGION 164..224
FT /note="IV (linker domain)"
FT REGION 225..308
FT /note="V (Cys-rich)"
FT CARBOHYD 72
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 149
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 56
FT /note="S -> T (in Ref. 3; AAH36679)"
FT /evidence="ECO:0000305"
FT CONFLICT 226..227
FT /note="KE -> RG (in Ref. 4; AAD02282)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="P -> Q (in Ref. 3; AAH36679)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 33065 MW; C18780A422AF6F6D CRC64;
MRLLPEWFLL LFGPWLLRKA VSAQIPESGR PQYLGLRPAA AGAGAPGQQL PEPRSSDGLG
VGRAWSWAWP TNHTGALARA GAAGALPAQR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF
SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PVPHPLQSTL
ALEGVLPGLG PPLGMAAAAA GPGLGGSLGG ALAGPLGGAL GVPGAKESRA FNCHVEYEKT
NRARKHRPCL YDPSQVCFTE HTQSQAAWLC AKPFKVICIF VSFLSFDYKL VQKVCPDYNF
QSEHPYFG
