ID   NXPH4_RAT               Reviewed;         304 AA.
AC   Q9Z2N4; Q642D9;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Neurexophilin-4;
DE   Flags: Precursor;
GN   Name=Nxph4; Synonyms=Nph4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=9570794; DOI=10.1523/jneurosci.18-10-03630.1998;
RA   Missler M., Suedhof T.C.;
RT   "Neurexophilins form a conserved family of neuropeptide-like
RT   glycoproteins.";
RL   J. Neurosci. 18:3630-3638(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be signaling molecules that resemble neuropeptides and
CC       that act by binding to alpha-neurexins and possibly other receptors.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Brain and kidney.
CC   -!- PTM: May be proteolytically processed in neuron-like cells.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the neurexophilin family. {ECO:0000305}.
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DR   EMBL; AF042714; AAD02227.1; -; mRNA.
DR   EMBL; BC081805; AAH81805.1; -; mRNA.
DR   RefSeq; NP_067712.2; NM_021680.2.
DR   RefSeq; XP_017450561.1; XM_017595072.1.
DR   AlphaFoldDB; Q9Z2N4; -.
DR   SMR; Q9Z2N4; -.
DR   STRING; 10116.ENSRNOP00000050310; -.
DR   GlyGen; Q9Z2N4; 4 sites.
DR   iPTMnet; Q9Z2N4; -.
DR   PhosphoSitePlus; Q9Z2N4; -.
DR   PaxDb; Q9Z2N4; -.
DR   GeneID; 59316; -.
DR   KEGG; rno:59316; -.
DR   UCSC; RGD:628723; rat.
DR   CTD; 11247; -.
DR   RGD; 628723; Nxph4.
DR   eggNOG; ENOG502QPNQ; Eukaryota.
DR   InParanoid; Q9Z2N4; -.
DR   OrthoDB; 1030335at2759; -.
DR   PhylomeDB; Q9Z2N4; -.
DR   TreeFam; TF333047; -.
DR   PRO; PR:Q9Z2N4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   InterPro; IPR010450; Nxph.
DR   InterPro; IPR026845; NXPH/NXPE.
DR   PANTHER; PTHR17103; PTHR17103; 1.
DR   Pfam; PF06312; Neurexophilin; 2.
DR   PIRSF; PIRSF038019; Neurexophilin; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..304
FT                   /note="Neurexophilin-4"
FT                   /id="PRO_0000020069"
FT   REGION          24..84
FT                   /note="II"
FT   REGION          85..163
FT                   /note="III"
FT   REGION          164..220
FT                   /note="IV (linker domain)"
FT   REGION          221..304
FT                   /note="V (Cys-rich)"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        143
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        191
FT                   /note="P -> T (in Ref. 2; AAH81805)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   304 AA;  32945 MW;  AD2B30B351DEDB4D CRC64;
     MRLLPEWLLL LFGPWLLRKV ISGQIVESGR PQYLDLRPAM AGGGARGQQL PVPASSEGLN
     PVRSWSWAWP ANHTGALARP GAAGGPPVPR TKRKPSIKAA RAKKIFGWGD FYFRVHTLKF
     SLLVTGKIVD HVNGTFSVYF RHNSSSLGNL SVSIVPPSKR VEFGGVWLPG PAPHPLQSTL
     ALEGVLPGLG PPLGMAGQGL GGNLGGALAG PLGGALGVPG AKESRAFNCH VEYEKTNRAR
     KHRPCLYDPS QVCFTEHTQS QAAWLCAKPF KVICIFVSFL SFDYKLVQKV CPDYNFQSEH
     PYFG