NXRD1_MOUSE
ID NXRD1_MOUSE Reviewed; 366 AA.
AC Q9D3S5;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein 1;
DE EC=1.-.-.-;
DE AltName: Full=Pyrroline-5-carboxylate reductase-like protein C14orf148 homolog;
GN Name=Noxred1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable oxidoreductase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC {ECO:0000305}.
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DR EMBL; AK017096; BAB30594.1; -; mRNA.
DR EMBL; BC125331; AAI25332.1; -; mRNA.
DR EMBL; BC125333; AAI25334.1; -; mRNA.
DR CCDS; CCDS36502.1; -.
DR RefSeq; NP_082020.1; NM_027744.1.
DR AlphaFoldDB; Q9D3S5; -.
DR SMR; Q9D3S5; -.
DR STRING; 10090.ENSMUSP00000021423; -.
DR iPTMnet; Q9D3S5; -.
DR PhosphoSitePlus; Q9D3S5; -.
DR PaxDb; Q9D3S5; -.
DR PRIDE; Q9D3S5; -.
DR ProteomicsDB; 287866; -.
DR Antibodypedia; 54657; 30 antibodies from 13 providers.
DR Ensembl; ENSMUST00000021423; ENSMUSP00000021423; ENSMUSG00000072919.
DR Ensembl; ENSMUST00000222480; ENSMUSP00000152486; ENSMUSG00000072919.
DR GeneID; 71275; -.
DR KEGG; mmu:71275; -.
DR UCSC; uc007oio.1; mouse.
DR CTD; 122945; -.
DR MGI; MGI:1918525; Noxred1.
DR VEuPathDB; HostDB:ENSMUSG00000072919; -.
DR eggNOG; KOG3124; Eukaryota.
DR GeneTree; ENSGT00950000183044; -.
DR HOGENOM; CLU_075978_0_0_1; -.
DR InParanoid; Q9D3S5; -.
DR OMA; YCDSFGI; -.
DR OrthoDB; 1123920at2759; -.
DR PhylomeDB; Q9D3S5; -.
DR TreeFam; TF335538; -.
DR BioGRID-ORCS; 71275; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9D3S5; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D3S5; protein.
DR Bgee; ENSMUSG00000072919; Expressed in seminiferous tubule of testis and 66 other tissues.
DR ExpressionAtlas; Q9D3S5; baseline and differential.
DR Genevisible; Q9D3S5; MM.
DR GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IBA:GO_Central.
DR GO; GO:0055129; P:L-proline biosynthetic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028939; P5C_Rdtase_cat_N.
DR InterPro; IPR000304; Pyrroline-COOH_reductase.
DR PANTHER; PTHR11645; PTHR11645; 1.
DR Pfam; PF03807; F420_oxidored; 1.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..366
FT /note="NADP-dependent oxidoreductase domain-containing
FT protein 1"
FT /id="PRO_0000280280"
SQ SEQUENCE 366 AA; 41666 MW; AF86FD2D1979611B CRC64;
MEMLEDLESL RFEFGIPEEE RYWLYLQGRY RGLMIKGCAH AAFFCKMFST LSNLLQNLPR
TIHPRTVSFD NAATEDELLT VGIIGCGHLG KQLTNVLLKT VPIPAENLQI STRRPESLGE
LRKLGVRCVY DNAAVASWAK VLFLCCLPAQ LPNICLEIQS KLNKHCTVYS FVSAIPLPRL
KSLLNHTNIL RPQYQFAEDY DNIWGENEEV PIALQDTTII RGTCPYNNLG GVILNVKWIE
GLCYALINAC TSRSVFHSQV LKLLNKLLLP MHLESCTTDP ESCPQFNLTD FMSKSYVKNL
YQKRPFPWFD LTTVQLKETP FSQHISATPS LQDHISLLYC EVFGLTISEE ELPYISTVIR
PLVEEK
