ID   NXRD1_XENTR             Reviewed;         344 AA.
AC   A0JM24;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein 1;
DE            EC=1.-.-.-;
DE   AltName: Full=Pyrroline-5-carboxylate reductase-like protein C14orf148 homolog;
GN   Name=noxred1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable oxidoreductase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.
CC       {ECO:0000305}.
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DR   EMBL; BC125710; AAI25711.1; -; mRNA.
DR   RefSeq; NP_001072734.1; NM_001079266.1.
DR   RefSeq; XP_012824145.1; XM_012968691.2.
DR   AlphaFoldDB; A0JM24; -.
DR   SMR; A0JM24; -.
DR   STRING; 8364.ENSXETP00000062804; -.
DR   PaxDb; A0JM24; -.
DR   DNASU; 780191; -.
DR   Ensembl; ENSXETT00000062784; ENSXETP00000062804; ENSXETG00000001302.
DR   GeneID; 780191; -.
DR   KEGG; xtr:780191; -.
DR   CTD; 122945; -.
DR   Xenbase; XB-GENE-968653; noxred1.
DR   eggNOG; KOG3124; Eukaryota.
DR   HOGENOM; CLU_075978_0_0_1; -.
DR   InParanoid; A0JM24; -.
DR   OMA; YCDSFGI; -.
DR   OrthoDB; 1123920at2759; -.
DR   PhylomeDB; A0JM24; -.
DR   TreeFam; TF335538; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001302; Expressed in testis and 5 other tissues.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IBA:GO_Central.
DR   GO; GO:0055129; P:L-proline biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR028939; P5C_Rdtase_cat_N.
DR   InterPro; IPR000304; Pyrroline-COOH_reductase.
DR   PANTHER; PTHR11645; PTHR11645; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..344
FT                   /note="NADP-dependent oxidoreductase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000280281"
SQ   SEQUENCE   344 AA;  37947 MW;  B405EDF7A518B9D2 CRC64;
     MLGITDLTAG LNSLQFEAGV EHKHESLLPL VGRSHILMLN ACAHCIYFCR LLLSCRQKEA
     GTGNPFAAHR IPLASRCERL RVSIIGGGNL GKQIAHCLID LGVIRAEDIR ISTRRPETLQ
     DLQELGVHCA YDNAALATWS QVIFLCCLPS QLPSICTEIR DHLKKACIVY SLVSGVPLSR
     LKQLLSHSSI IRPDYKYEAK DGALVHGKKR TITANLKDLS VVKSTSIGIF QKEGICVLNR
     FIETSMYAAL NMCSLQGLSS KEALTLLNAL IPQTQPLDLA SSLLTPEAFV SSEFISSLSD
     ESPFPWFDLC TVQSKETPFS EYLARSLWLR TGLEELYLAA FKTP