ID   NXT1_BOVIN              Reviewed;         140 AA.
AC   Q2KIW0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=NTF2-related export protein 1;
GN   Name=NXT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulator of protein export for NES-containing proteins.
CC       Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA.
CC       The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in
CC       conjunction with ALYREF/THOC4 and THOC5 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with NXF1. Forms a complex with RANGAP1,
CC       RANBP2/NUP358 and NXF1. Interacts (via NTF2 domain) with NXF1.
CC       Stabilizes the NTF2 domain of NXF1 by heterodimerization. The formation
CC       of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear
CC       mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3
CC       and NXF5. Does not bind nucleoporins (NPC) directly, its association to
CC       NPC is mediated by NXF1. {ECO:0000250|UniProtKB:Q9UKK6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the
CC       nucleus and the cytoplasm. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC112489; AAI12490.1; -; mRNA.
DR   RefSeq; NP_001069273.1; NM_001075805.1.
DR   AlphaFoldDB; Q2KIW0; -.
DR   SMR; Q2KIW0; -.
DR   STRING; 9913.ENSBTAP00000006568; -.
DR   PaxDb; Q2KIW0; -.
DR   PRIDE; Q2KIW0; -.
DR   GeneID; 520351; -.
DR   KEGG; bta:520351; -.
DR   CTD; 29107; -.
DR   eggNOG; KOG4353; Eukaryota.
DR   InParanoid; Q2KIW0; -.
DR   OrthoDB; 1450028at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00780; NTF2; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR045875; NTF2/Mtr2.
DR   InterPro; IPR002075; NTF2_dom.
DR   InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR   PANTHER; PTHR12612; PTHR12612; 1.
DR   Pfam; PF02136; NTF2; 1.
DR   SUPFAM; SSF54427; SSF54427; 1.
DR   PROSITE; PS50177; NTF2_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; mRNA transport; Nucleus; Protein transport;
KW   Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKK6"
FT   CHAIN           2..140
FT                   /note="NTF2-related export protein 1"
FT                   /id="PRO_0000247806"
FT   DOMAIN          16..135
FT                   /note="NTF2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKK6"
SQ   SEQUENCE   140 AA;  15832 MW;  1F8EB39A790F5477 CRC64;
     MASVDFKTYV GQACRAAEEF VNVYYSTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE
     FFEMLPSSEF QINVVDCQPV HDEATPSQTT VLVVICGTVK FEGNKQRDFN QNFILTAQAS
     PSNTVWKIAS DCFRFQDWAC