NXT1_CAEEL
ID NXT1_CAEEL Reviewed; 137 AA.
AC Q9U757;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=NTF2-related export protein;
GN Name=nxt-1; Synonyms=nxt1; ORFNames=Y71F9AM.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10567585; DOI=10.1128/mcb.19.12.8616;
RA Black B.E., Levesque L., Holaska J.M., Wood T.C., Paschal B.M.;
RT "Identification of an NTF2-related factor that binds Ran-GTP and regulates
RT nuclear protein export.";
RL Mol. Cell. Biol. 19:8616-8624(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Stimulator of protein export for NES-containing proteins.
CC Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Preferentially binds Ran-GTP. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9U757; Q9XVS8: nxf-2; NbExp=5; IntAct=EBI-2006451, EBI-2007577;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; AF156960; AAD54945.1; -; mRNA.
DR EMBL; FO081820; CCD73516.1; -; Genomic_DNA.
DR RefSeq; NP_491077.1; NM_058676.4.
DR PDB; 3NV0; X-ray; 1.84 A; B=2-137.
DR PDBsum; 3NV0; -.
DR AlphaFoldDB; Q9U757; -.
DR SMR; Q9U757; -.
DR BioGRID; 37344; 2.
DR IntAct; Q9U757; 1.
DR STRING; 6239.Y71F9AM.5a; -.
DR EPD; Q9U757; -.
DR PaxDb; Q9U757; -.
DR EnsemblMetazoa; Y71F9AM.5a.1; Y71F9AM.5a.1; WBGene00003836.
DR GeneID; 171866; -.
DR KEGG; cel:CELE_Y71F9AM.5; -.
DR UCSC; Y71F9AM.5b; c. elegans.
DR CTD; 171866; -.
DR WormBase; Y71F9AM.5a; CE26780; WBGene00003836; nxt-1.
DR eggNOG; KOG4353; Eukaryota.
DR GeneTree; ENSGT00940000170896; -.
DR InParanoid; Q9U757; -.
DR OMA; DHFTRLY; -.
DR OrthoDB; 1450028at2759; -.
DR PhylomeDB; Q9U757; -.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR PRO; PR:Q9U757; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003836; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q9U757; baseline and differential.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR CDD; cd00780; NTF2; 1.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR045875; NTF2/Mtr2.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR PANTHER; PTHR12612; PTHR12612; 1.
DR Pfam; PF02136; NTF2; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure; mRNA transport; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..137
FT /note="NTF2-related export protein"
FT /id="PRO_0000194797"
FT DOMAIN 19..135
FT /note="NTF2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT HELIX 6..33
FT /evidence="ECO:0007829|PDB:3NV0"
FT HELIX 35..41
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 42..50
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:3NV0"
FT HELIX 58..67
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 71..82
FT /evidence="ECO:0007829|PDB:3NV0"
FT HELIX 89..91
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 95..105
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 111..122
FT /evidence="ECO:0007829|PDB:3NV0"
FT STRAND 125..135
FT /evidence="ECO:0007829|PDB:3NV0"
SQ SEQUENCE 137 AA; 15479 MW; B99ABE3CA3479962 CRC64;
MSMKTTQEIN KEDEELCNES KKFMDVYYDV MDRKREKIGF LYTQVSNAVW NGNPINGYDS
ICEFMKALPS TQHDIQSLDA QRLPEGVTGD MSGGMLLNVA GAVTVDGDSK RAFTQTLLLG
VEDGKYKVKS DRFRYVD
