NXT2_MOUSE
ID NXT2_MOUSE Reviewed; 142 AA.
AC Q3UNA4; B1AVX3; B1AVX5; Q505F8; Q6NVE1; Q8C070;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=NTF2-related export protein 2;
GN Name=Nxt2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulator of protein export for NES-containing proteins. Also
CC plays a role in mRNA nuclear export (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Associates with NXF1, NXF2, NXF3 and NXF5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q3UNA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UNA4-2; Sequence=VSP_037529;
CC Name=3;
CC IsoId=Q3UNA4-3; Sequence=VSP_037528;
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DR EMBL; AK032102; BAC27701.1; -; mRNA.
DR EMBL; AK144349; BAE25843.1; -; mRNA.
DR EMBL; AL731672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466610; EDL14753.1; -; Genomic_DNA.
DR EMBL; CH466610; EDL14754.1; -; Genomic_DNA.
DR EMBL; BC068166; AAH68166.2; -; mRNA.
DR EMBL; BC094570; AAH94570.2; -; mRNA.
DR EMBL; BC118503; AAI18504.1; -; mRNA.
DR CCDS; CCDS41155.1; -. [Q3UNA4-1]
DR CCDS; CCDS72440.1; -. [Q3UNA4-2]
DR CCDS; CCDS72441.1; -. [Q3UNA4-3]
DR RefSeq; NP_001154902.1; NM_001161430.2. [Q3UNA4-1]
DR RefSeq; NP_001277461.1; NM_001290532.1. [Q3UNA4-2]
DR RefSeq; NP_001277462.1; NM_001290533.1. [Q3UNA4-3]
DR RefSeq; NP_766370.2; NM_172782.4. [Q3UNA4-1]
DR AlphaFoldDB; Q3UNA4; -.
DR SMR; Q3UNA4; -.
DR BioGRID; 231838; 4.
DR STRING; 10090.ENSMUSP00000048221; -.
DR iPTMnet; Q3UNA4; -.
DR PhosphoSitePlus; Q3UNA4; -.
DR MaxQB; Q3UNA4; -.
DR PaxDb; Q3UNA4; -.
DR PeptideAtlas; Q3UNA4; -.
DR PRIDE; Q3UNA4; -.
DR ProteomicsDB; 287868; -. [Q3UNA4-1]
DR ProteomicsDB; 287869; -. [Q3UNA4-2]
DR ProteomicsDB; 287870; -. [Q3UNA4-3]
DR Antibodypedia; 15334; 42 antibodies from 18 providers.
DR DNASU; 237082; -.
DR Ensembl; ENSMUST00000042329; ENSMUSP00000048221; ENSMUSG00000042271. [Q3UNA4-1]
DR Ensembl; ENSMUST00000112913; ENSMUSP00000108535; ENSMUSG00000042271. [Q3UNA4-3]
DR Ensembl; ENSMUST00000112914; ENSMUSP00000108536; ENSMUSG00000042271. [Q3UNA4-1]
DR Ensembl; ENSMUST00000112916; ENSMUSP00000108538; ENSMUSG00000042271. [Q3UNA4-2]
DR GeneID; 237082; -.
DR KEGG; mmu:237082; -.
DR UCSC; uc009ulr.3; mouse. [Q3UNA4-1]
DR UCSC; uc057asw.1; mouse. [Q3UNA4-2]
DR CTD; 55916; -.
DR MGI; MGI:2147914; Nxt2.
DR VEuPathDB; HostDB:ENSMUSG00000042271; -.
DR eggNOG; KOG4353; Eukaryota.
DR GeneTree; ENSGT00940000156381; -.
DR HOGENOM; CLU_122448_1_0_1; -.
DR InParanoid; Q3UNA4; -.
DR OrthoDB; 1450028at2759; -.
DR TreeFam; TF318944; -.
DR BioGRID-ORCS; 237082; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Nxt2; mouse.
DR PRO; PR:Q3UNA4; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q3UNA4; protein.
DR Bgee; ENSMUSG00000042271; Expressed in cerebellum lobe and 207 other tissues.
DR Genevisible; Q3UNA4; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0044613; C:nuclear pore central transport channel; IBA:GO_Central.
DR GO; GO:0042272; C:nuclear RNA export factor complex; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006913; P:nucleocytoplasmic transport; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR CDD; cd00780; NTF2; 1.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR045875; NTF2/Mtr2.
DR InterPro; IPR002075; NTF2_dom.
DR InterPro; IPR018222; Nuclear_transport_factor_2_euk.
DR PANTHER; PTHR12612; PTHR12612; 1.
DR Pfam; PF02136; NTF2; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
DR PROSITE; PS50177; NTF2_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; mRNA transport; Nucleus;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..142
FT /note="NTF2-related export protein 2"
FT /id="PRO_0000378200"
FT DOMAIN 17..136
FT /note="NTF2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00137"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_037528"
FT VAR_SEQ 1
FT /note="M -> MKKFRSNWSNGDQHFGNSGSSWVEPQINYKYQRTQTSAEVRTSPGPA
FT LEQTISSPLM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_037529"
FT CONFLICT 11
FT /note="V -> L (in Ref. 1; BAC27701)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 16257 MW; 104CB5006E62A07C CRC64;
MALAVNFKTY VDQACRAAEE FVNIYYETMD KRRHALVRLY LDKATLIWNG NVVTGLEALA
NFFEMLPSSE FQINMLDCQP VHEQATQCQT TVLVVTSGVV KFDGNKQHFF NQNFLLTAQS
TPNSTVWKIA SDCFRFQDWA SI
