NYAP1_HUMAN
ID NYAP1_HUMAN Reviewed; 841 AA.
AC Q6ZVC0; Q6U9Y3; Q8N1V0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1;
GN Name=NYAP1; Synonyms=C7orf51;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain, and Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 585-841 (ISOFORM 2).
RA Zhou G., Yu R., Zhong G., Li H., Shen C., Ke R., Li M., Lin L., Yang S.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex
CC to the close vicinity of PI3K and regulates neuronal morphogenesis.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with
CC components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction
CC mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q6ZVC0; Q9Y490: TLN1; NbExp=2; IntAct=EBI-20847847, EBI-2462036;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZVC0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZVC0-2; Sequence=VSP_031746;
CC -!- PTM: Phosphorylated on tyrosine residues by FYN upon stimulation with
CC CNTN5. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NYAP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04437.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK094857; BAC04437.1; ALT_INIT; mRNA.
DR EMBL; AK124773; BAC85942.1; -; mRNA.
DR EMBL; CH236956; EAL23830.1; -; Genomic_DNA.
DR EMBL; AY375450; AAQ83634.1; -; mRNA.
DR CCDS; CCDS5696.1; -. [Q6ZVC0-1]
DR RefSeq; NP_775835.2; NM_173564.3. [Q6ZVC0-1]
DR RefSeq; XP_006715970.1; XM_006715907.3.
DR AlphaFoldDB; Q6ZVC0; -.
DR BioGRID; 128821; 10.
DR IntAct; Q6ZVC0; 6.
DR STRING; 9606.ENSP00000300179; -.
DR CarbonylDB; Q6ZVC0; -.
DR iPTMnet; Q6ZVC0; -.
DR PhosphoSitePlus; Q6ZVC0; -.
DR BioMuta; NYAP1; -.
DR DMDM; 74712216; -.
DR MassIVE; Q6ZVC0; -.
DR PaxDb; Q6ZVC0; -.
DR PeptideAtlas; Q6ZVC0; -.
DR PRIDE; Q6ZVC0; -.
DR ProteomicsDB; 68404; -. [Q6ZVC0-1]
DR ProteomicsDB; 68405; -. [Q6ZVC0-2]
DR Antibodypedia; 16487; 9 antibodies from 8 providers.
DR DNASU; 222950; -.
DR Ensembl; ENST00000300179.7; ENSP00000300179.2; ENSG00000166924.9. [Q6ZVC0-1]
DR GeneID; 222950; -.
DR KEGG; hsa:222950; -.
DR MANE-Select; ENST00000300179.7; ENSP00000300179.2; NM_173564.4; NP_775835.2.
DR UCSC; uc003uvd.3; human. [Q6ZVC0-1]
DR CTD; 222950; -.
DR DisGeNET; 222950; -.
DR GeneCards; NYAP1; -.
DR HGNC; HGNC:22009; NYAP1.
DR HPA; ENSG00000166924; Tissue enhanced (brain, pituitary gland).
DR MIM; 615477; gene.
DR neXtProt; NX_Q6ZVC0; -.
DR OpenTargets; ENSG00000166924; -.
DR PharmGKB; PA162380561; -.
DR VEuPathDB; HostDB:ENSG00000166924; -.
DR eggNOG; ENOG502QRSX; Eukaryota.
DR GeneTree; ENSGT00890000139453; -.
DR InParanoid; Q6ZVC0; -.
DR OMA; CHSKEPT; -.
DR OrthoDB; 620667at2759; -.
DR PhylomeDB; Q6ZVC0; -.
DR PathwayCommons; Q6ZVC0; -.
DR SignaLink; Q6ZVC0; -.
DR BioGRID-ORCS; 222950; 31 hits in 1066 CRISPR screens.
DR ChiTaRS; NYAP1; human.
DR GenomeRNAi; 222950; -.
DR Pharos; Q6ZVC0; Tdark.
DR PRO; PR:Q6ZVC0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6ZVC0; protein.
DR Bgee; ENSG00000166924; Expressed in cortical plate and 96 other tissues.
DR ExpressionAtlas; Q6ZVC0; baseline and differential.
DR Genevisible; Q6ZVC0; HS.
DR GO; GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
DR InterPro; IPR026724; NYAP1.
DR InterPro; IPR026722; NYAP1/NYAP2.
DR InterPro; IPR029353; NYAP_C.
DR InterPro; IPR039482; NYAP_N.
DR PANTHER; PTHR22633; PTHR22633; 1.
DR PANTHER; PTHR22633:SF2; PTHR22633:SF2; 1.
DR Pfam; PF15452; NYAP_C; 1.
DR Pfam; PF15439; NYAP_N; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..841
FT /note="Neuronal tyrosine-phosphorylated phosphoinositide-3-
FT kinase adapter 1"
FT /id="PRO_0000320929"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 64..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..186
FT /note="Involved in CYFIP1- and NCKAP1-binding"
FT /evidence="ECO:0000250"
FT REGION 655..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..296
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..394
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 649
FT /note="K -> TE (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_031746"
FT CONFLICT 707
FT /note="I -> V (in Ref. 3; AAQ83634)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 841 AA; 87928 MW; 56899E3AAA922FA5 CRC64;
MNLLYRKTKL EWRQHKEEEA KRSSSKEVAP AGSAGPAAGQ GPGVRVRDIA SLRRSLRMGF
MTMPASQEHT PHPCRSAMAP RSLSCHSVGS MDSVGGGPGG ASGGLTEDSS TRRPPAKPRR
HPSTKLSMVG PGSGAETPPS KKAGSQKPTP EGRESSRKVP PQKPRRSPNT QLSVSFDESC
PPGPSPRGGN LPLQRLTRGS RVAGDPDVGA QEEPVYIEMV GDVFRGGGRS GGGLAGPPLG
GGGPTPPAGA DSDSEESEAI YEEMKYPLPE EAGEGRANGP PPLTATSPPQ QPHALPPHAH
RRPASALPSR RDGTPTKTTP CEIPPPFPNL LQHRPPLLAF PQAKSASRTP GDGVSRLPVL
CHSKEPAGST PAPQVPARER ETPPPPPPPP AANLLLLGPS GRARSHSTPL PPQGSGQPRG
ERELPNSHSM ICPKAAGAPA APPAPAALLP GPPKDKAVSY TMVYSAVKVT THSVLPAGPP
LGAGEPKTEK EISVLHGMLC TSSRPPVPGK TSPHGGAMGA AAGVLHHRGC LASPHSLPDP
TVGPLTPLWT YPATAAGLKR PPAYESLKAG GVLNKGCGVG APSPMVKIQL QEQGTDGGAF
ASISCAHVIA SAGTPEEEEE EVGAATFGAG WALQRKVLYG GRKAKELDKV EDGARAWNGS
AEGPGKVERE DRGPGTSGIP VRSQGAEGLL ARIHHGDRGG SRTALPIPCQ TFPACHRNGD
FTGGYRLGRS ASTSGVRQVV LHTPRPCSQP RDALSQPHPA LPLPLPLPPQ PARERDGKLL
EVIERKRCVC KEIKARHRPD RGLCKQESMP ILPSWRRGPE PRKSGTPPCR RQHTVLWDTA
I
