O1002_MOUSE
ID O1002_MOUSE Reviewed; 318 AA.
AC Q8VFK2; A2ALD0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Olfactory receptor 1002;
DE AltName: Full=Olfactory receptor 175-2;
GN Name=Olfr1002; Synonyms=Mor175-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073524; AAL61187.1; -; Genomic_DNA.
DR EMBL; AY318196; AAP71457.1; -; Genomic_DNA.
DR EMBL; AL773585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16212.1; -.
DR RefSeq; NP_666784.2; NM_146573.2.
DR AlphaFoldDB; Q8VFK2; -.
DR SMR; Q8VFK2; -.
DR STRING; 10090.ENSMUSP00000097504; -.
DR GlyGen; Q8VFK2; 1 site.
DR PhosphoSitePlus; Q8VFK2; -.
DR PaxDb; Q8VFK2; -.
DR PRIDE; Q8VFK2; -.
DR DNASU; 258566; -.
DR Ensembl; ENSMUST00000099920; ENSMUSP00000097504; ENSMUSG00000075214.
DR Ensembl; ENSMUST00000215548; ENSMUSP00000150405; ENSMUSG00000075214.
DR GeneID; 258566; -.
DR KEGG; mmu:258566; -.
DR UCSC; uc008kkn.1; mouse.
DR CTD; 258566; -.
DR MGI; MGI:3030836; Olfr1002.
DR VEuPathDB; HostDB:ENSMUSG00000075214; -.
DR eggNOG; ENOG502RF13; Eukaryota.
DR GeneTree; ENSGT01050000244931; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFK2; -.
DR OMA; CGPQIIN; -.
DR OrthoDB; 971463at2759; -.
DR PhylomeDB; Q8VFK2; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258566; 0 hits in 45 CRISPR screens.
DR PRO; PR:Q8VFK2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VFK2; protein.
DR Genevisible; Q8VFK2; MM.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 1002"
FT /id="PRO_0000150858"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 222
FT /note="A -> T (in Ref. 1; AAL61187)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 35833 MW; 5A49C526E0CB5DCA CRC64;
MMHRNQTVVT EFFFTGLTSS FHLQIVLFLT FLCVYLATLL GNLGMIILIH QDTRLHIPMY
FFLSHLSFVD ACSSSVISPK MLSDIFVDKK VISFLGCAIQ FCLFSQFVVT ECFLLASMAY
DRYVAICKPL LYTLIMSQRV CVQLVIGPYS IGLISTVVHT TSAFILPYCG PNLINHFFCD
LLPVLSLACA DTQMNKHLLF IMAGILGVFS GIIILVSYVY IAITILKINS ADGRRKAFST
CSSHLTAVSI LYGTLFFIYV RPSSSFSLDI NKVVSLFYTA VIPMLNPFIY SLRNKEVKDA
LIRTFEKKFC YSLQDKIL
