O1019_MOUSE
ID O1019_MOUSE Reviewed; 310 AA.
AC Q8VGS3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 1019;
DE AltName: Full=Olfactory receptor 180-1;
GN Name=Olfr1019; Synonyms=Mor180-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [4]
RP FUNCTION, ACTIVITY REGULATION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF
RP CYS-203; MET-256 AND ARG-261.
RX PubMed=29659735; DOI=10.1093/chemse/bjy022;
RA Zhang R., Pan Y., Ahmed L., Block E., Zhang Y., Batista V.S., Zhuang H.;
RT "A Multispecific Investigation of the Metal Effect in Mammalian Odorant
RT Receptors for Sulfur-containing Compounds.";
RL Chem. Senses 43:357-366(2018).
CC -!- FUNCTION: Olfactory receptor that is activated by the binding of
CC organosulfur odorants with thioether groups such as
CC (methylthio)methanethiol (MTMT). The activity of this receptor is
CC mediated by G proteins which activate adenylyl cyclase (Probable).
CC {ECO:0000269|PubMed:29659735, ECO:0000305}.
CC -!- ACTIVITY REGULATION: Copper binding enhances receptor activity in
CC response to odorant binding. {ECO:0000269|PubMed:29659735}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29659735};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073073; AAL60736.1; -; Genomic_DNA.
DR EMBL; AY318214; AAP71469.1; -; Genomic_DNA.
DR CCDS; CCDS16223.1; -.
DR RefSeq; NP_667226.1; NM_147015.1.
DR AlphaFoldDB; Q8VGS3; -.
DR SMR; Q8VGS3; -.
DR STRING; 10090.ENSMUSP00000099694; -.
DR GlyGen; Q8VGS3; 1 site.
DR PhosphoSitePlus; Q8VGS3; -.
DR PaxDb; Q8VGS3; -.
DR PRIDE; Q8VGS3; -.
DR Antibodypedia; 78755; 46 antibodies from 14 providers.
DR Ensembl; ENSMUST00000102634; ENSMUSP00000099694; ENSMUSG00000075208.
DR Ensembl; ENSMUST00000213515; ENSMUSP00000150622; ENSMUSG00000075208.
DR GeneID; 259017; -.
DR KEGG; mmu:259017; -.
DR UCSC; uc008kkz.1; mouse.
DR CTD; 259017; -.
DR MGI; MGI:3030853; Olfr1019.
DR VEuPathDB; HostDB:ENSMUSG00000075208; -.
DR eggNOG; ENOG502SHXT; Eukaryota.
DR GeneTree; ENSGT01050000244954; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q8VGS3; -.
DR OMA; TGITQDP; -.
DR OrthoDB; 963494at2759; -.
DR PhylomeDB; Q8VGS3; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 259017; 3 hits in 66 CRISPR screens.
DR PRO; PR:Q8VGS3; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VGS3; protein.
DR ExpressionAtlas; Q8VGS3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB.
DR GO; GO:0005507; F:copper ion binding; IMP:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IMP:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IMP:UniProtKB.
DR GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IMP:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Copper; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Metal-binding; Olfaction; Receptor;
KW Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 1019"
FT /id="PRO_0000150860"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT BINDING 203
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:29659735"
FT BINDING 256
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:29659735"
FT BINDING 261
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000305|PubMed:29659735"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT MUTAGEN 203
FT /note="C->S: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 256
FT /note="M->A: Decreased receptor activity in response to
FT MTMT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
FT MUTAGEN 261
FT /note="R->W,H,A: No receptor activity in response to MTMT
FT binding, even in the presence of copper."
FT /evidence="ECO:0000269|PubMed:29659735"
SQ SEQUENCE 310 AA; 34860 MW; 27F64FBDCA3AA41A CRC64;
MDKENHSVVT EFVFMGITQD PQLQIIFFVV FLLVYLVNVI GNVGMIILII TDSQLHTPMY
FFLCNLSFVD LGYSSAIAPR MLADFLTKHK VISFSSCATQ FAFFVGFVDA ECYVLAAMAY
DRFVAICRPL HYSTLMSKKV CLVLMLGSYF AGLVSLVAHT SLTFSLSYCG SNIINHFFCE
IPPLLALSCS DTYISEILLF SLCGFIEFST ILIIFISYAF ILIAIIRIRS AEGRLKAFST
CGSHLTGVTL FYGTVMFMYL RPTSSYSLDQ DKWASVFYTI IIPMLNPLIY SLRNKDVKAA
FKKLIGKKPQ
