O1086_MOUSE
ID O1086_MOUSE Reviewed; 310 AA.
AC Q8VFL9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Olfactory receptor 1086;
DE AltName: Full=Olfactory receptor 179-2;
GN Name=Olfr1086; Synonyms=Mor179-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073505; AAL61168.1; -; Genomic_DNA.
DR EMBL; AY318282; AAP71514.1; -; Genomic_DNA.
DR CCDS; CCDS16264.1; -.
DR RefSeq; NP_666803.1; NM_146592.1.
DR AlphaFoldDB; Q8VFL9; -.
DR SMR; Q8VFL9; -.
DR STRING; 10090.ENSMUSP00000097463; -.
DR GlyGen; Q8VFL9; 1 site.
DR PaxDb; Q8VFL9; -.
DR PRIDE; Q8VFL9; -.
DR Ensembl; ENSMUST00000099878; ENSMUSP00000097463; ENSMUSG00000075175.
DR Ensembl; ENSMUST00000213198; ENSMUSP00000150094; ENSMUSG00000075175.
DR GeneID; 258585; -.
DR KEGG; mmu:258585; -.
DR UCSC; uc008kmt.1; mouse.
DR CTD; 258585; -.
DR MGI; MGI:3030920; Olfr1086.
DR VEuPathDB; HostDB:ENSMUSG00000075175; -.
DR eggNOG; ENOG502SHA3; Eukaryota.
DR GeneTree; ENSGT00940000153301; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8VFL9; -.
DR OMA; TAVSIFH; -.
DR OrthoDB; 960379at2759; -.
DR PhylomeDB; Q8VFL9; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258585; 4 hits in 66 CRISPR screens.
DR PRO; PR:Q8VFL9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VFL9; protein.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 1086"
FT /id="PRO_0000150866"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..194
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 95..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34661 MW; 18FDE87C8FD07CD8 CRC64;
MENITEVTEF ILMGFTDNAD LEILSFFLFL AIYLFTLMGN LGLITLVIGD SRLHNPMYYF
LSVLSSVDAC YSTVITPQMV VDFVSEKKVI SFIGCATQMF LAVTFGTTEC FLLAAMAYDR
YVAIHNPLMY VVSMSPRVYV PLIIASYAGG ILHAVIHTVA TFRLSFCGSN KISHIFCDIP
PLLAISCSDT HFNQLLLFYC AGFIEVVTIL IVLLSYGFIL SVILKTRSTE GKRKVFSTCG
SHLMAVSTFH GTVLFMYVRP SDSYALEHDM MVSIFYSIVI PMLNPLIYSL RNKDVKEAIK
KVFGKRILCG
