O10A2_HUMAN
ID O10A2_HUMAN Reviewed; 303 AA.
AC Q9H208; B2RNL9; Q6IFG9;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Olfactory receptor 10A2;
DE AltName: Full=HP4;
DE AltName: Full=Olfactory receptor OR11-86;
GN Name=OR10A2; Synonyms=OR10A2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-134.
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-134.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 55-270, AND VARIANT ARG-207.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG45207.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A2";
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DR EMBL; AF321237; AAG45207.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC017103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136955; AAI36956.1; -; mRNA.
DR EMBL; AF399624; AAK95109.1; -; Genomic_DNA.
DR EMBL; BK004293; DAA04691.1; -; Genomic_DNA.
DR CCDS; CCDS31415.1; -.
DR RefSeq; NP_001004460.1; NM_001004460.1.
DR AlphaFoldDB; Q9H208; -.
DR SMR; Q9H208; -.
DR IntAct; Q9H208; 1.
DR STRING; 9606.ENSP00000303862; -.
DR iPTMnet; Q9H208; -.
DR PhosphoSitePlus; Q9H208; -.
DR BioMuta; OR10A2; -.
DR DMDM; 118573088; -.
DR MassIVE; Q9H208; -.
DR PaxDb; Q9H208; -.
DR PRIDE; Q9H208; -.
DR TopDownProteomics; Q9H208; -.
DR Antibodypedia; 56602; 41 antibodies from 10 providers.
DR DNASU; 341276; -.
DR Ensembl; ENST00000641461.1; ENSP00000493131.1; ENSG00000170790.6.
DR GeneID; 341276; -.
DR KEGG; hsa:341276; -.
DR MANE-Select; ENST00000641461.1; ENSP00000493131.1; NM_001004460.2; NP_001004460.1.
DR UCSC; uc001meu.2; human.
DR CTD; 341276; -.
DR GeneCards; OR10A2; -.
DR HGNC; HGNC:8161; OR10A2.
DR HPA; ENSG00000170790; Not detected.
DR neXtProt; NX_Q9H208; -.
DR PharmGKB; PA31950; -.
DR VEuPathDB; HostDB:ENSG00000170790; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244815; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9H208; -.
DR OMA; CRTNKVN; -.
DR OrthoDB; 1098110at2759; -.
DR PhylomeDB; Q9H208; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q9H208; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 341276; 3 hits in 635 CRISPR screens.
DR GenomeRNAi; 341276; -.
DR Pharos; Q9H208; Tdark.
DR PRO; PR:Q9H208; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H208; protein.
DR Bgee; ENSG00000170790; Expressed in primary visual cortex and 6 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..303
FT /note="Olfactory receptor 10A2"
FT /id="PRO_0000261139"
FT TOPO_DOM 1..12
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..184
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 84..176
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 43
FT /note="H -> R (in dbSNP:rs3930075)"
FT /id="VAR_060022"
FT VARIANT 134
FT /note="A -> T (in dbSNP:rs2741764)"
FT /evidence="ECO:0000269|PubMed:11416212,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_053261"
FT VARIANT 207
FT /note="H -> R (in dbSNP:rs10839631)"
FT /evidence="ECO:0000269|PubMed:12213199"
FT /id="VAR_034277"
FT VARIANT 240
FT /note="I -> T (in dbSNP:rs10839632)"
FT /id="VAR_034278"
FT VARIANT 258
FT /note="K -> T (in dbSNP:rs7926083)"
FT /id="VAR_034279"
FT CONFLICT 173
FT /note="R -> K (in Ref. 4; AAK95109)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="N -> H (in Ref. 4; AAK95109)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 303 AA; 33817 MW; 6B7A103BBB8ED190 CRC64;
MSFSSLPTEI QSLLFLTFLT IYLVTLMGNC LIILVTLADP MLHSPMYFFL RNLSFLEIGF
NLVIVPKMLG TLLAQDTTIS FLGCATQMYF FFFFGVAECF LLATMAYDRY VAICSPLHYP
VIMNQRTRAK LAAASWFPGF PVATVQTTWL FSFPFCGTNK VNHFFCDSPP VLRLVCADTA
LFEIYAIVGT ILVVMIPCLL ILCSYTHIAA AILKIPSAKG KNKAFSTCSS HLLVVSLFYI
SLSLTYFRPK SNNSPEGKKL LSLSYTVMTP MLNPIIYSLR NNEVKNALSR TVSKALALRN
CIP
