O10A3_HUMAN
ID O10A3_HUMAN Reviewed; 314 AA.
AC P58181; B9EH39; Q6IF58; Q96R11;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Olfactory receptor 10A3;
DE AltName: Full=HTPCRX12;
DE AltName: Full=Olfactory receptor OR11-97;
GN Name=OR10A3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
RN [7]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [8]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A3";
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DR EMBL; AB065768; BAC05988.1; -; Genomic_DNA.
DR EMBL; AC044810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68641.1; -; Genomic_DNA.
DR EMBL; BC137031; AAI37032.1; -; mRNA.
DR EMBL; BC137032; AAI37033.1; -; mRNA.
DR EMBL; AF399634; AAK95119.1; -; Genomic_DNA.
DR EMBL; X64986; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004404; DAA04802.1; -; Genomic_DNA.
DR CCDS; CCDS31421.1; -.
DR RefSeq; NP_001003745.1; NM_001003745.1.
DR AlphaFoldDB; P58181; -.
DR SMR; P58181; -.
DR STRING; 9606.ENSP00000353988; -.
DR GlyGen; P58181; 1 site.
DR iPTMnet; P58181; -.
DR PhosphoSitePlus; P58181; -.
DR BioMuta; OR10A3; -.
DR DMDM; 14423787; -.
DR MassIVE; P58181; -.
DR PaxDb; P58181; -.
DR PeptideAtlas; P58181; -.
DR PRIDE; P58181; -.
DR Antibodypedia; 55077; 17 antibodies from 12 providers.
DR DNASU; 26496; -.
DR Ensembl; ENST00000612788.1; ENSP00000484096.1; ENSG00000273953.1.
DR Ensembl; ENST00000626843.1; ENSP00000487530.1; ENSG00000281680.2.
DR Ensembl; ENST00000641438.1; ENSP00000493029.1; ENSG00000281680.2.
DR Ensembl; ENST00000642047.1; ENSP00000493303.1; ENSG00000170683.7.
DR GeneID; 26496; -.
DR KEGG; hsa:26496; -.
DR MANE-Select; ENST00000642047.1; ENSP00000493303.1; NM_001003745.2; NP_001003745.1.
DR UCSC; uc010rbi.3; human.
DR CTD; 26496; -.
DR GeneCards; OR10A3; -.
DR HGNC; HGNC:8162; OR10A3.
DR HPA; ENSG00000170683; Not detected.
DR neXtProt; NX_P58181; -.
DR OpenTargets; ENSG00000170683; -.
DR PharmGKB; PA31951; -.
DR VEuPathDB; HostDB:ENSG00000170683; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; P58181; -.
DR OMA; VMFSWIS; -.
DR OrthoDB; 857288at2759; -.
DR PhylomeDB; P58181; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; P58181; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26496; 4 hits in 668 CRISPR screens.
DR GeneWiki; OR10A3; -.
DR GenomeRNAi; 26496; -.
DR Pharos; P58181; Tdark.
DR PRO; PR:P58181; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P58181; protein.
DR Bgee; ENSG00000170683; Expressed in skin of leg and 2 other tissues.
DR ExpressionAtlas; P58181; baseline and differential.
DR Genevisible; P58181; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 10A3"
FT /id="PRO_0000150685"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 20
FT /note="F -> V (in dbSNP:rs16934214)"
FT /id="VAR_053262"
SQ SEQUENCE 314 AA; 35535 MW; 3355B17F4AFBF647 CRC64;
MKRQNQSCVV EFILLGFSNF PELQVQLFGV FLVIYVVTLM GNAIITVIIS LNQSLHVPMY
LFLLNLSVVE VSFSAVITPE MLVVLSTEKT MISFVGCFAQ MYFILLFGGT ECFLLGAMAY
DRFAAICHPL NYPVIMNRGV FMKLVIFSWI SGIMVATVQT TWVFSFPFCG PNEINHLFCE
TPPVLELVCA DTFLFEIYAF TGTILIVMVP FLLILLSYIR VLFAILKMPS TTGRQKAFST
CASHLTSVTL FYGTANMTYL QPKSGYSPET KKLISLAYTL LTPLLNPLIY SLRNSEMKRT
LIKLWRRKVI LHTF
