O10A4_HUMAN
ID O10A4_HUMAN Reviewed; 315 AA.
AC Q9H209; B2RNP5; B9EH36; Q96R20;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Olfactory receptor 10A4;
DE AltName: Full=HP2;
DE AltName: Full=Olfactory receptor-like protein JCG5;
GN Name=OR10A4; Synonyms=OR10A4P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PRO-206.
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT PRO-206.
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-262.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, AND VARIANT PRO-206.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A4";
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DR EMBL; AF321237; AAG45205.1; -; Genomic_DNA.
DR EMBL; AF209506; AAL32993.1; -; mRNA.
DR EMBL; AC087280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471064; EAW68674.1; -; Genomic_DNA.
DR EMBL; BC137024; AAI37025.1; -; mRNA.
DR EMBL; BC137027; AAI37028.1; -; mRNA.
DR EMBL; AF399625; AAK95110.1; -; Genomic_DNA.
DR CCDS; CCDS7774.1; -.
DR RefSeq; NP_997069.2; NM_207186.2.
DR AlphaFoldDB; Q9H209; -.
DR SMR; Q9H209; -.
DR BioGRID; 129519; 5.
DR STRING; 9606.ENSP00000369157; -.
DR GlyGen; Q9H209; 1 site.
DR BioMuta; OR10A4; -.
DR DMDM; 296439244; -.
DR MassIVE; Q9H209; -.
DR PaxDb; Q9H209; -.
DR PRIDE; Q9H209; -.
DR Antibodypedia; 54733; 100 antibodies from 19 providers.
DR DNASU; 283297; -.
DR Ensembl; ENST00000379829.2; ENSP00000369157.2; ENSG00000170782.3.
DR GeneID; 283297; -.
DR KEGG; hsa:283297; -.
DR MANE-Select; ENST00000379829.2; ENSP00000369157.2; NM_207186.2; NP_997069.2.
DR UCSC; uc010rat.2; human.
DR CTD; 283297; -.
DR DisGeNET; 283297; -.
DR GeneCards; OR10A4; -.
DR HGNC; HGNC:15130; OR10A4.
DR HPA; ENSG00000170782; Not detected.
DR neXtProt; NX_Q9H209; -.
DR OpenTargets; ENSG00000170782; -.
DR PharmGKB; PA31952; -.
DR VEuPathDB; HostDB:ENSG00000170782; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244815; -.
DR HOGENOM; CLU_012526_1_2_1; -.
DR InParanoid; Q9H209; -.
DR OMA; MMWENWT; -.
DR OrthoDB; 1098110at2759; -.
DR PhylomeDB; Q9H209; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q9H209; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 283297; 6 hits in 672 CRISPR screens.
DR GeneWiki; OR10A4; -.
DR GenomeRNAi; 283297; -.
DR Pharos; Q9H209; Tbio.
DR PRO; PR:Q9H209; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H209; protein.
DR Bgee; ENSG00000170782; Expressed in bone marrow cell and 5 other tissues.
DR Genevisible; Q9H209; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 10A4"
FT /id="PRO_0000150686"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 206
FT /note="L -> P (in dbSNP:rs2595453)"
FT /evidence="ECO:0000269|PubMed:11416212,
FT ECO:0000269|PubMed:11705801, ECO:0000269|PubMed:12213199"
FT /id="VAR_060023"
FT VARIANT 221
FT /note="R -> H (in dbSNP:rs7938371)"
FT /id="VAR_034280"
FT VARIANT 246
FT /note="L -> F (in dbSNP:rs16919049)"
FT /id="VAR_034281"
FT VARIANT 262
FT /note="R -> Q (in dbSNP:rs10839635)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_024124"
SQ SEQUENCE 315 AA; 35117 MW; C8DF67959FDACBFC CRC64;
MMWENWTIVS EFVLVSFSAL STELQALLFL LFLTIYLVTL MGNVLIILVT IADSALQSPM
YFFLRNLSFL EIGFNLVIVP KMLGTLIIQD TTISFLGCAT QMYFFFFFGA AECCLLATMA
YDRYVAICDP LHYPVIMGHI SCAQLAAASW FSGFSVATVQ TTWIFSFPFC GPNRVNHFFC
DSPPVIALVC ADTSVFELEA LTATVLFILF PFLLILGSYV RILSTIFRMP SAEGKHQAFS
TCSAHLLVVS LFYSTAILTY FRPQSSASSE SKKLLSLSST VVTPMLNPII YSSRNKEVKA
ALKRLIHRTL GSQKL
