O10A5_HUMAN
ID O10A5_HUMAN Reviewed; 317 AA.
AC Q9H207; O95223; Q52M66; Q96R21; Q96R22;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Olfactory receptor 10A5;
DE AltName: Full=HP3;
DE AltName: Full=Olfactory receptor 10A1;
DE AltName: Full=Olfactory receptor 11-403;
DE Short=OR11-403;
DE AltName: Full=Olfactory receptor-like protein JCG6;
GN Name=OR10A5; Synonyms=OR10A1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tongue;
RX PubMed=11705801; DOI=10.1093/chemse/26.9.1157;
RA Gaudin J.-C., Breuils L., Haertle T.;
RT "New GPCRs from a human lingual cDNA library.";
RL Chem. Senses 26:1157-1166(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11416212; DOI=10.1073/pnas.131215398;
RA Lane R.P., Cutforth T., Young J., Athanasiou M., Friedman C., Rowen L.,
RA Evans G., Axel R., Hood L., Trask B.J.;
RT "Genomic analysis of orthologous mouse and human olfactory receptor loci.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7390-7395(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-288.
RX PubMed=9787077; DOI=10.1006/geno.1998.5422;
RA Buettner J.A., Glusman G., Ben-Arie N., Ramos P., Lancet D., Evans G.A.;
RT "Organization and evolution of olfactory receptor genes on human chromosome
RT 11.";
RL Genomics 53:56-68(1998).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
CC -!- FUNCTION: Odorant receptor (Potential). May be involved in taste
CC perception. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the tongue.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A5";
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DR EMBL; AF324499; AAL33005.1; -; mRNA.
DR EMBL; AF321237; AAG45206.1; -; Genomic_DNA.
DR EMBL; BC093651; AAH93651.1; -; mRNA.
DR EMBL; BC093653; AAH93653.1; -; mRNA.
DR EMBL; AF065874; AAC70019.1; -; Genomic_DNA.
DR EMBL; AF399623; AAK95108.1; -; Genomic_DNA.
DR CCDS; CCDS7773.1; -.
DR RefSeq; NP_835462.1; NM_178168.1.
DR AlphaFoldDB; Q9H207; -.
DR SMR; Q9H207; -.
DR IntAct; Q9H207; 1.
DR STRING; 9606.ENSP00000299454; -.
DR GlyGen; Q9H207; 1 site.
DR iPTMnet; Q9H207; -.
DR PhosphoSitePlus; Q9H207; -.
DR BioMuta; OR10A5; -.
DR DMDM; 14423805; -.
DR MassIVE; Q9H207; -.
DR PaxDb; Q9H207; -.
DR PeptideAtlas; Q9H207; -.
DR PRIDE; Q9H207; -.
DR ProteomicsDB; 80467; -.
DR TopDownProteomics; Q9H207; -.
DR Antibodypedia; 56597; 51 antibodies from 14 providers.
DR DNASU; 144124; -.
DR Ensembl; ENST00000299454.5; ENSP00000299454.4; ENSG00000166363.6.
DR GeneID; 144124; -.
DR KEGG; hsa:144124; -.
DR MANE-Select; ENST00000299454.5; ENSP00000299454.4; NM_178168.1; NP_835462.1.
DR UCSC; uc001met.2; human.
DR CTD; 144124; -.
DR GeneCards; OR10A5; -.
DR HGNC; HGNC:15131; OR10A5.
DR HPA; ENSG00000166363; Not detected.
DR MIM; 608493; gene.
DR neXtProt; NX_Q9H207; -.
DR OpenTargets; ENSG00000166363; -.
DR PharmGKB; PA31953; -.
DR VEuPathDB; HostDB:ENSG00000166363; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244815; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9H207; -.
DR OMA; WTEISEF; -.
DR OrthoDB; 1098110at2759; -.
DR PhylomeDB; Q9H207; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q9H207; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 144124; 5 hits in 620 CRISPR screens.
DR GeneWiki; OR10A5; -.
DR GenomeRNAi; 144124; -.
DR Pharos; Q9H207; Tdark.
DR PRO; PR:Q9H207; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q9H207; protein.
DR Bgee; ENSG00000166363; Expressed in corpus callosum and 5 other tissues.
DR ExpressionAtlas; Q9H207; baseline and differential.
DR Genevisible; Q9H207; HS.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 10A5"
FT /id="PRO_0000150687"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 41
FT /note="K -> M (in dbSNP:rs7949377)"
FT /id="VAR_034282"
FT CONFLICT 256
FT /note="S -> L (in Ref. 4; AAC70019)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="W -> R (in Ref. 4; AAC70019)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="S -> G (in Ref. 4; AAC70019)"
FT /evidence="ECO:0000305"
FT CONFLICT 282
FT /note="V -> M (in Ref. 4; AAC70019)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 35519 MW; 464073EFC4EC5B45 CRC64;
MAIGNWTEIS EFILMSFSSL PTEIQSLLFL TFLTIYLVTL KGNSLIILVT LADPMLHSPM
YFFLRNLSFL EIGFNLVIVP KMLGTLLAQD TTISFLGCAT QMYFFFFFGV AECFLLATMA
YDRYVAICSP LHYPVIMNQR TRAKLAAASW FPGFPVATVQ TTWLFSFPFC GTNKVNHFFC
DSPPVLKLVC ADTALFEIYA IVGTILVVMI PCLLILCSYT RIAAAILKIP SAKGKHKAFS
TCSSHLLVVS LFYISSSLTY FWPKSNNSPE SKKLLSLSYT VVTPMLNPII YSLRNSEVKN
ALSRTFHKVL ALRNCIP
