O10A6_HUMAN
ID O10A6_HUMAN Reviewed; 314 AA.
AC Q8NH74; Q6IF59;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Olfactory receptor 10A6;
DE AltName: Full=Olfactory receptor OR11-96;
GN Name=OR10A6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A6";
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DR EMBL; AB065515; BAC05763.1; -; Genomic_DNA.
DR EMBL; BK004403; DAA04801.1; -; Genomic_DNA.
DR RefSeq; NP_001004461.1; NM_001004461.1.
DR AlphaFoldDB; Q8NH74; -.
DR SMR; Q8NH74; -.
DR STRING; 9606.ENSP00000312470; -.
DR GlyGen; Q8NH74; 1 site.
DR PhosphoSitePlus; Q8NH74; -.
DR BioMuta; OR10A6; -.
DR DMDM; 38372823; -.
DR PaxDb; Q8NH74; -.
DR PRIDE; Q8NH74; -.
DR Antibodypedia; 78355; 59 antibodies from 16 providers.
DR DNASU; 390093; -.
DR Ensembl; ENST00000622207.2; ENSP00000478945.1; ENSG00000276451.2.
DR Ensembl; ENST00000625231.2; ENSP00000486810.1; ENSG00000280899.3.
DR Ensembl; ENST00000641238.1; ENSP00000493068.1; ENSG00000279000.4.
DR Ensembl; ENST00000641640.1; ENSP00000493246.1; ENSG00000280899.3.
DR Ensembl; ENST00000641884.1; ENSP00000493158.1; ENSG00000280899.3.
DR Ensembl; ENST00000642108.1; ENSP00000492919.1; ENSG00000279000.4.
DR GeneID; 390093; -.
DR KEGG; hsa:390093; -.
DR MANE-Select; ENST00000641238.1; ENSP00000493068.1; NM_001004461.2; NP_001004461.1.
DR UCSC; uc010rbh.2; human.
DR CTD; 390093; -.
DR GeneCards; OR10A6; -.
DR HGNC; HGNC:15132; OR10A6.
DR HPA; ENSG00000279000; Not detected.
DR neXtProt; NX_Q8NH74; -.
DR PharmGKB; PA31954; -.
DR VEuPathDB; HostDB:ENSG00000279000; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NH74; -.
DR OMA; KLLMMSW; -.
DR OrthoDB; 857288at2759; -.
DR PhylomeDB; Q8NH74; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NH74; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390093; 3 hits in 659 CRISPR screens.
DR GeneWiki; OR10A6; -.
DR GenomeRNAi; 390093; -.
DR Pharos; Q8NH74; Tdark.
DR PRO; PR:Q8NH74; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH74; protein.
DR Bgee; ENSG00000279000; Expressed in skin of leg and 4 other tissues.
DR ExpressionAtlas; Q8NH74; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 10A6"
FT /id="PRO_0000150689"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 117
FT /note="A -> V (in dbSNP:rs7928451)"
FT /id="VAR_053263"
FT VARIANT 140
FT /note="V -> G (in dbSNP:rs7933807)"
FT /id="VAR_053264"
FT VARIANT 287
FT /note="L -> P (in dbSNP:rs4758258)"
FT /id="VAR_053265"
SQ SEQUENCE 314 AA; 35318 MW; 22453498F86381FB CRC64;
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY
LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ MYFILLFGGA ECFLLGAMAY
DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE
TPAVLELACA DTFLFEIYAF TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST
CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA
LMKLWRRRVV LHTI
