ID   O10A7_HUMAN             Reviewed;         316 AA.
AC   Q8NGE5; Q6IFD5; Q96R19;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=Olfactory receptor 10A7;
DE   AltName: Full=Olfactory receptor OR12-6;
GN   Name=OR10A7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A7";
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DR   EMBL; AB065864; BAC06082.1; -; Genomic_DNA.
DR   EMBL; AF399626; AAK95111.1; -; Genomic_DNA.
DR   EMBL; BK004327; DAA04725.1; -; Genomic_DNA.
DR   CCDS; CCDS31815.1; -.
DR   RefSeq; NP_001005280.1; NM_001005280.1.
DR   AlphaFoldDB; Q8NGE5; -.
DR   SMR; Q8NGE5; -.
DR   STRING; 9606.ENSP00000326718; -.
DR   GlyGen; Q8NGE5; 1 site.
DR   iPTMnet; Q8NGE5; -.
DR   PhosphoSitePlus; Q8NGE5; -.
DR   BioMuta; OR10A7; -.
DR   DMDM; 38372676; -.
DR   MassIVE; Q8NGE5; -.
DR   PaxDb; Q8NGE5; -.
DR   PeptideAtlas; Q8NGE5; -.
DR   PRIDE; Q8NGE5; -.
DR   ProteomicsDB; 73490; -.
DR   Antibodypedia; 58533; 47 antibodies from 19 providers.
DR   DNASU; 121364; -.
DR   Ensembl; ENST00000326258.1; ENSP00000326718.1; ENSG00000179919.3.
DR   GeneID; 121364; -.
DR   KEGG; hsa:121364; -.
DR   MANE-Select; ENST00000326258.1; ENSP00000326718.1; NM_001005280.1; NP_001005280.1.
DR   UCSC; uc010spf.2; human.
DR   CTD; 121364; -.
DR   GeneCards; OR10A7; -.
DR   HGNC; HGNC:15329; OR10A7.
DR   HPA; ENSG00000179919; Not detected.
DR   neXtProt; NX_Q8NGE5; -.
DR   PharmGKB; PA31955; -.
DR   VEuPathDB; HostDB:ENSG00000179919; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01050000244815; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NGE5; -.
DR   OMA; TTTYEMQ; -.
DR   OrthoDB; 1098110at2759; -.
DR   PhylomeDB; Q8NGE5; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q8NGE5; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NGE5; -.
DR   BioGRID-ORCS; 121364; 9 hits in 671 CRISPR screens.
DR   GeneWiki; OR10A7; -.
DR   GenomeRNAi; 121364; -.
DR   Pharos; Q8NGE5; Tdark.
DR   PRO; PR:Q8NGE5; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8NGE5; protein.
DR   ExpressionAtlas; Q8NGE5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..316
FT                   /note="Olfactory receptor 10A7"
FT                   /id="PRO_0000150690"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..316
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         96
FT                   /note="G -> S (in dbSNP:rs12578318)"
FT                   /id="VAR_053266"
SQ   SEQUENCE   316 AA;  35695 MW;  A01AA01481C7FBBE CRC64;
     MICENHTRVT EFILLGFTNN PEMQVSLFIF FLAIYTVTLL GNFLIVTVTS VDLALQTPMY
     FFLQNLSLLE VCFTLVMVPK MLVDLVSPRK IISFVGCGTQ MYFFFFFGSS ECFLLSMMAY
     DRFVAICNPL HYSVIMNRSL CLWMAIGSWM SGVPVSMLQT AWMMALPFCG PNAVDHFFCD
     GPPVLKLVTV DTTMYEMQAL ASTLLFIMFP FCLILVSYTR IIITILRMSS ATGRQKAFST
     CSSHLIVVSL FYGTASLTYL RPKSNQSPES KKLVSLSYTV ITPMLNPIIY GLRNNEVKGA
     VKRTITQKVL QKLDVF