O10AC_HUMAN
ID O10AC_HUMAN Reviewed; 325 AA.
AC Q8NH08;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Olfactory receptor 10AC1;
DE AltName: Full=Olfactory receptor OR7-5;
GN Name=OR10AC1; Synonyms=OR10AC1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- POLYMORPHISM: A stop codon due to a single nucleotide insertion in the
CC gene coding for this protein at position Ile-90 is responsible for
CC functional diversity thus producing a pseudogene. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10AC1P";
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DR EMBL; AB065605; BAC05833.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BK004748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q8NH08; -.
DR SMR; Q8NH08; -.
DR GlyGen; Q8NH08; 1 site.
DR BioMuta; OR10AC1; -.
DR DMDM; 281185475; -.
DR MassIVE; Q8NH08; -.
DR PRIDE; Q8NH08; -.
DR ProteomicsDB; 73644; -.
DR GeneCards; OR10AC1; -.
DR HGNC; HGNC:14758; OR10AC1.
DR neXtProt; NX_Q8NH08; -.
DR InParanoid; Q8NH08; -.
DR PhylomeDB; Q8NH08; -.
DR PathwayCommons; Q8NH08; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NH08; Tdark.
DR PRO; PR:Q8NH08; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8NH08; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Olfactory receptor 10AC1"
FT /id="PRO_0000349381"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..171
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 193..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 325 AA; 35157 MW; 08D0D6F3D72C3B05 CRC64;
MDSPSNATVP CGFLLQGFSE FPHLRPVLFL LLLGVHLATL GGNLLILVAV ASMPSRQPML
LFLCQLSAIE LCYTLVVVPR SLVDLSTPGH RRGSPISFLS CAFQMQMFVA LGGAECFLLA
AMAYDRYVAI CHPLRYAAVV TPGLCARLAL ACCLRGLAVS VGLTVAIFHL PFCGSRLLLH
FFCDITALLH LACTRSYADE LPLLGACLVL LLLPSVLILA SYGAIAAALR RLRCPKGRGK
AASTCALHLA VTFLHYGCAT FMYVRPRASY SPRLDRTLAL VYTNVTPLLC PLIYSLRNRE
ITAALSRVLG RRRPGQAPGG DLREL
