O10AD_HUMAN
ID O10AD_HUMAN Reviewed; 317 AA.
AC Q8NGE0; B9EGT9; Q6IFA8;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Olfactory receptor 10AD1;
DE AltName: Full=Olfactory receptor OR12-1;
GN Name=OR10AD1; Synonyms=OR10AD1P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10AD1";
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DR EMBL; AB065872; BAC06090.1; -; Genomic_DNA.
DR EMBL; BC136757; AAI36758.1; -; mRNA.
DR EMBL; BC136758; AAI36759.1; -; mRNA.
DR EMBL; BK004354; DAA04752.1; -; Genomic_DNA.
DR CCDS; CCDS31787.1; -.
DR RefSeq; NP_001004134.1; NM_001004134.1.
DR AlphaFoldDB; Q8NGE0; -.
DR SMR; Q8NGE0; -.
DR STRING; 9606.ENSP00000308689; -.
DR GlyGen; Q8NGE0; 1 site.
DR BioMuta; OR10AD1; -.
DR DMDM; 38258177; -.
DR PaxDb; Q8NGE0; -.
DR PeptideAtlas; Q8NGE0; -.
DR PRIDE; Q8NGE0; -.
DR Antibodypedia; 57040; 107 antibodies from 23 providers.
DR DNASU; 121275; -.
DR Ensembl; ENST00000310248.4; ENSP00000308689.2; ENSG00000172640.4.
DR GeneID; 121275; -.
DR KEGG; hsa:121275; -.
DR MANE-Select; ENST00000310248.4; ENSP00000308689.2; NM_001004134.1; NP_001004134.1.
DR UCSC; uc001rrl.2; human.
DR CTD; 121275; -.
DR DisGeNET; 121275; -.
DR GeneCards; OR10AD1; -.
DR HGNC; HGNC:14819; OR10AD1.
DR HPA; ENSG00000172640; Tissue enhanced (brain, retina).
DR neXtProt; NX_Q8NGE0; -.
DR PharmGKB; PA31959; -.
DR VEuPathDB; HostDB:ENSG00000172640; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244837; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGE0; -.
DR OMA; QMYFVFC; -.
DR OrthoDB; 1167989at2759; -.
DR PhylomeDB; Q8NGE0; -.
DR TreeFam; TF338235; -.
DR PathwayCommons; Q8NGE0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 121275; 12 hits in 668 CRISPR screens.
DR GeneWiki; OR10AD1; -.
DR GenomeRNAi; 121275; -.
DR Pharos; Q8NGE0; Tdark.
DR PRO; PR:Q8NGE0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NGE0; protein.
DR Bgee; ENSG00000172640; Expressed in sural nerve and 79 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..317
FT /note="Olfactory receptor 10AD1"
FT /id="PRO_0000150691"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 8
FT /note="V -> A (in dbSNP:rs17122812)"
FT /id="VAR_053267"
FT VARIANT 166
FT /note="R -> Q (in dbSNP:rs17224674)"
FT /id="VAR_053268"
FT VARIANT 275
FT /note="F -> V (in dbSNP:rs11830378)"
FT /id="VAR_053269"
FT VARIANT 279
FT /note="Y -> H (in dbSNP:rs11168459)"
FT /id="VAR_024125"
SQ SEQUENCE 317 AA; 35698 MW; 72D856594467060F CRC64;
MLRNGSIVTE FILVGFQQSS TSTRALLFAL FLALYSLTMA MNGLIIFITS WTDPKLNSPM
YFFLGHLSLL DVCFITTTIP QMLIHLVVRD HIVSFVCCMT QMYFVFCVGV AECILLAFMA
YDRYVAICYP LNYVPIISQK VCVRLVGTAW FFGLINGIFL EYISFREPFR RDNHIESFFC
EAPIVIGLSC GDPQFSLWAI FADAIVVILS PMVLTVTSYV HILATILSKA SSSGRGKTFS
TCASHLTVVI FLYTSAMFSY MNPHSTHGPD KDKPFSLLYT IITPMCNPII YSFRNKEIKE
AMVRALGRTR LAQPQSV
