O10AG_HUMAN
ID O10AG_HUMAN Reviewed; 301 AA.
AC Q8NH19; B2RNH4; Q6IEU3;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 10AG1;
DE AltName: Full=Olfactory receptor OR11-160;
GN Name=OR10AG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8NH19; P41181: AQP2; NbExp=3; IntAct=EBI-13339917, EBI-12701138;
CC Q8NH19; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-13339917, EBI-6942903;
CC Q8NH19; O00559: EBAG9; NbExp=3; IntAct=EBI-13339917, EBI-8787095;
CC Q8NH19; O15552: FFAR2; NbExp=3; IntAct=EBI-13339917, EBI-2833872;
CC Q8NH19; P15941-11: MUC1; NbExp=3; IntAct=EBI-13339917, EBI-17263240;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10AG1";
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DR EMBL; AB065594; BAC05822.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73692.1; -; Genomic_DNA.
DR EMBL; BC136890; AAI36891.1; -; mRNA.
DR EMBL; BC136891; AAI36892.1; -; mRNA.
DR EMBL; BK004519; DAA04917.1; -; Genomic_DNA.
DR RefSeq; NP_001005491.1; NM_001005491.1.
DR AlphaFoldDB; Q8NH19; -.
DR SMR; Q8NH19; -.
DR BioGRID; 129411; 5.
DR IntAct; Q8NH19; 5.
DR STRING; 9606.ENSP00000311477; -.
DR GlyGen; Q8NH19; 1 site.
DR iPTMnet; Q8NH19; -.
DR PhosphoSitePlus; Q8NH19; -.
DR BioMuta; OR10AG1; -.
DR DMDM; 38503050; -.
DR PaxDb; Q8NH19; -.
DR PeptideAtlas; Q8NH19; -.
DR PRIDE; Q8NH19; -.
DR Antibodypedia; 58952; 101 antibodies from 22 providers.
DR DNASU; 282770; -.
DR Ensembl; ENST00000312345.4; ENSP00000311477.2; ENSG00000174970.5.
DR GeneID; 282770; -.
DR KEGG; hsa:282770; -.
DR UCSC; uc010rit.2; human.
DR CTD; 282770; -.
DR GeneCards; OR10AG1; -.
DR HGNC; HGNC:19607; OR10AG1.
DR HPA; ENSG00000174970; Not detected.
DR neXtProt; NX_Q8NH19; -.
DR PharmGKB; PA134929321; -.
DR VEuPathDB; HostDB:ENSG00000174970; -.
DR eggNOG; ENOG502SI62; Eukaryota.
DR GeneTree; ENSGT01050000244815; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NH19; -.
DR OrthoDB; 910033at2759; -.
DR PhylomeDB; Q8NH19; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q8NH19; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH19; -.
DR BioGRID-ORCS; 282770; 7 hits in 671 CRISPR screens.
DR GeneWiki; OR10AG1; -.
DR GenomeRNAi; 282770; -.
DR Pharos; Q8NH19; Tdark.
DR PRO; PR:Q8NH19; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH19; protein.
DR ExpressionAtlas; Q8NH19; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..301
FT /note="Olfactory receptor 10AG1"
FT /id="PRO_0000150692"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 88..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 301 AA; 34105 MW; BDDC23BD2F3D6822 CRC64;
MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM YFFLSNFSLL
EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG TECLLLTVMA YDRYVAICKP
LQYPLVMNHK VCIQLIIASW TITIPVVIGE TCQIFLLPFC GTNTINHFFC DIPPILKLAC
GNIFVNEITV HVVAVVFITV PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI
LFFGAGTITY LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL
T
