O10C1_HUMAN
ID O10C1_HUMAN Reviewed; 312 AA.
AC Q96KK4; Q5SUN7; Q96R18;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Olfactory receptor 10C1;
DE AltName: Full=Hs6M1-17;
DE AltName: Full=Olfactory receptor 10C2;
GN Name=OR10C1; Synonyms=OR10C2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-246.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-282, AND VARIANT VAL-246.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP POLYMORPHISM.
RX PubMed=12730696; DOI=10.1038/ng1160;
RA Menashe I., Man O., Lancet D., Gilad Y.;
RT "Different noses for different people.";
RL Nat. Genet. 34:143-144(2003).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: A stop codon at position Gln-55 in the gene coding for
CC this protein is responsible for functional diversity thus producing a
CC pseudogene. The stop codon is more frequent in African-Americans than
CC in non-Africans.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB44507.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10C2";
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DR EMBL; AL035542; CAB44507.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL645927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC136996; AAI36997.1; -; mRNA.
DR EMBL; BC136997; AAI36998.1; -; mRNA.
DR EMBL; AF399627; AAK95112.1; -; Genomic_DNA.
DR CCDS; CCDS34364.1; -.
DR RefSeq; NP_039229.3; NM_013941.3.
DR AlphaFoldDB; Q96KK4; -.
DR SMR; Q96KK4; -.
DR STRING; 9606.ENSP00000485032; -.
DR GlyGen; Q96KK4; 1 site.
DR iPTMnet; Q96KK4; -.
DR PhosphoSitePlus; Q96KK4; -.
DR BioMuta; OR10C1; -.
DR DMDM; 296439284; -.
DR MassIVE; Q96KK4; -.
DR PaxDb; Q96KK4; -.
DR PRIDE; Q96KK4; -.
DR Antibodypedia; 57682; 56 antibodies from 18 providers.
DR DNASU; 442194; -.
DR Ensembl; ENST00000377138.1; ENSP00000366343.1; ENSG00000229412.5.
DR Ensembl; ENST00000391549.2; ENSP00000375393.2; ENSG00000204689.7.
DR Ensembl; ENST00000437403.1; ENSP00000408961.1; ENSG00000224234.5.
DR Ensembl; ENST00000444197.3; ENSP00000419119.1; ENSG00000206474.8.
DR Ensembl; ENST00000455234.1; ENSP00000402486.1; ENSG00000230505.4.
DR Ensembl; ENST00000457403.1; ENSP00000412512.1; ENSG00000232397.5.
DR GeneID; 442194; -.
DR KEGG; hsa:442194; -.
DR MANE-Select; ENST00000444197.3; ENSP00000419119.1; NM_013941.4; NP_039229.3.
DR UCSC; uc011dlp.3; human.
DR CTD; 442194; -.
DR GeneCards; OR10C1; -.
DR HGNC; HGNC:8165; OR10C1.
DR HPA; ENSG00000206474; Not detected.
DR neXtProt; NX_Q96KK4; -.
DR VEuPathDB; HostDB:ENSG00000206474; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01050000244815; -.
DR HOGENOM; CLU_012526_0_1_1; -.
DR InParanoid; Q96KK4; -.
DR OMA; CGPNAIP; -.
DR OrthoDB; 910033at2759; -.
DR PhylomeDB; Q96KK4; -.
DR TreeFam; TF337350; -.
DR PathwayCommons; Q96KK4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 442194; 43 hits in 668 CRISPR screens.
DR GeneWiki; OR10C1; -.
DR GenomeRNAi; 442194; -.
DR Pharos; Q96KK4; Tdark.
DR PRO; PR:Q96KK4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96KK4; protein.
DR Bgee; ENSG00000206474; Expressed in bone marrow cell.
DR ExpressionAtlas; Q96KK4; baseline and differential.
DR Genevisible; Q96KK4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Olfactory receptor 10C1"
FT /id="PRO_0000150693"
FT TOPO_DOM 1..24
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..45
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 46..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 57
FT /note="P -> S (in dbSNP:rs17184016)"
FT /id="VAR_037822"
FT VARIANT 60
FT /note="F -> L (in dbSNP:rs2074469)"
FT /id="VAR_037823"
FT VARIANT 89
FT /note="R -> S (in dbSNP:rs11755182)"
FT /id="VAR_037824"
FT VARIANT 100
FT /note="M -> V (in dbSNP:rs17177632)"
FT /id="VAR_037825"
FT VARIANT 121
FT /note="R -> C (in dbSNP:rs17177639)"
FT /id="VAR_037826"
FT VARIANT 138
FT /note="R -> W (in dbSNP:rs17177646)"
FT /id="VAR_037827"
FT VARIANT 160
FT /note="P -> S (in dbSNP:rs2074468)"
FT /id="VAR_037828"
FT VARIANT 161
FT /note="F -> L (in dbSNP:rs2074467)"
FT /id="VAR_037829"
FT VARIANT 174
FT /note="P -> Q (in dbSNP:rs2074466)"
FT /id="VAR_037830"
FT VARIANT 246
FT /note="M -> V (in dbSNP:rs2074464)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:14574404"
FT /id="VAR_037831"
FT VARIANT 255
FT /note="L -> I (in dbSNP:rs17177674)"
FT /id="VAR_037832"
FT VARIANT 310
FT /note="M -> R (in dbSNP:rs11968123)"
FT /id="VAR_037833"
SQ SEQUENCE 312 AA; 34384 MW; B6FD7A4A2018F69C CRC64;
MSANTSMVTE FLLLGFSHLA DLQGLLFSVF LTIYLLTVAG NFLIVVLVST DAALQSPMYF
FLRTLSALEI GYTSVTVPLL LHHLLTGRRH ISRSGCALQM FFFLFFGATE CCLLAAMAYD
RYAAICEPLR YPLLLSHRVC LQLAGSAWAC GVLVGLGHTP FIFSLPFCGP NTIPQFFCEI
QPVLQLVCGD TSLNELQIIL ATALLILCPF GLILGSYGRI LVTIFRIPSV AGRRKAFSTC
SSHLIMVSLF YGTALFIYIR PKASYDPATD PLVSLFYAVV TPILNPIIYS LRNTEVKAAL
KRTIQKTVPM EI
