ARPIN_DANRE
ID ARPIN_DANRE Reviewed; 226 AA.
AC Q1LWJ6; Q561T7;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Arpin;
GN Name=arpin; ORFNames=zgc:112432;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=24132237; DOI=10.1038/nature12611;
RA Dang I., Gorelik R., Sousa-Blin C., Derivery E., Guerin C., Linkner J.,
RA Nemethova M., Dumortier J.G., Giger F.A., Chipysheva T.A., Ermilova V.D.,
RA Vacher S., Campanacci V., Herrada I., Planson A.G., Fetics S., Henriot V.,
RA David V., Oguievetskaia K., Lakisic G., Pierre F., Steffen A., Boyreau A.,
RA Peyrieras N., Rottner K., Zinn-Justin S., Cherfils J., Bieche I.,
RA Alexandrova A.Y., David N.B., Small J.V., Faix J., Blanchoin L.,
RA Gautreau A.;
RT "Inhibitory signalling to the Arp2/3 complex steers cell migration.";
RL Nature 503:281-284(2013).
CC -!- FUNCTION: Regulates actin polymerization by inhibiting the actin-
CC nucleating activity of the Arp2/3 complex; the function is competitive
CC with nucleation promoting factors (By similarity). Involved in steering
CC cell migration by controlling its directional persistence.
CC {ECO:0000250, ECO:0000269|PubMed:24132237}.
CC -!- SUBUNIT: Associates with the Arp2/3 complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}.
CC -!- DOMAIN: The acidic C-terminus is necessary and sufficient to inhibit
CC ARP2/3 complex activity. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Arpin family. {ECO:0000305}.
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DR EMBL; BX548061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC093306; AAH93306.1; -; mRNA.
DR RefSeq; NP_001017780.1; NM_001017780.1.
DR AlphaFoldDB; Q1LWJ6; -.
DR SASBDB; Q1LWJ6; -.
DR STRING; 7955.ENSDARP00000091551; -.
DR PaxDb; Q1LWJ6; -.
DR DNASU; 550477; -.
DR Ensembl; ENSDART00000100778; ENSDARP00000091551; ENSDARG00000041085.
DR GeneID; 550477; -.
DR KEGG; dre:550477; -.
DR CTD; 348110; -.
DR ZFIN; ZDB-GENE-050417-304; arpin.
DR eggNOG; ENOG502R4IG; Eukaryota.
DR GeneTree; ENSGT00530000064251; -.
DR HOGENOM; CLU_106544_0_0_1; -.
DR InParanoid; Q1LWJ6; -.
DR OMA; HLMSSYK; -.
DR OrthoDB; 1431350at2759; -.
DR PhylomeDB; Q1LWJ6; -.
DR PRO; PR:Q1LWJ6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 18.
DR Bgee; ENSDARG00000041085; Expressed in swim bladder and 23 other tissues.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0033058; P:directional locomotion; IDA:UniProtKB.
DR GO; GO:0051126; P:negative regulation of actin nucleation; IBA:GO_Central.
DR GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR InterPro; IPR018889; Arpin.
DR PANTHER; PTHR31199; PTHR31199; 1.
DR Pfam; PF10574; UPF0552; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Reference proteome.
FT CHAIN 1..226
FT /note="Arpin"
FT /id="PRO_0000424789"
FT REGION 197..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 100
FT /note="Y -> F (in Ref. 2; AAH93306)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="F -> S (in Ref. 2; AAH93306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 226 AA; 25622 MW; 038896BF253DB046 CRC64;
MSRIYDNTAL LNKPVHNEKL SFTWDPIVHQ SGHGVILEGT VVDFSRHAIT DVKNRKERYN
VLYIKPSRVH RRKYDSKGNE IEPNFSDTKK VNTGFLMSSY KVEAKGETDC LDERQLREIV
NKEQLVKVTI KHCPREAFAF WISEAEMDKT ELEPGQEVRL KTKGDGPFIF SFAKLDSGTV
TKCNFAGDEN AGASWTEKIM ANKSNQENTG KSAAQGEGAD DDEWDD
