O10D3_HUMAN
ID O10D3_HUMAN Reviewed; 312 AA.
AC Q8NH80;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Putative olfactory receptor 10D3;
DE AltName: Full=HTPCRX09;
DE AltName: Full=Olfactory receptor OR11-293;
GN Name=OR10D3; Synonyms=OR10D3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10D3P";
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DR EMBL; AB065509; BAC05757.1; -; Genomic_DNA.
DR EMBL; X64983; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004425; DAA04823.1; -; Genomic_DNA.
DR CCDS; CCDS86257.1; -.
DR AlphaFoldDB; Q8NH80; -.
DR SMR; Q8NH80; -.
DR STRING; 9606.ENSP00000323895; -.
DR BioMuta; OR10D3; -.
DR DMDM; 74760322; -.
DR PaxDb; Q8NH80; -.
DR PeptideAtlas; Q8NH80; -.
DR PRIDE; Q8NH80; -.
DR Antibodypedia; 65551; 7 antibodies from 7 providers.
DR Ensembl; ENST00000318666.6; ENSP00000323895.6; ENSG00000197309.4.
DR Ensembl; ENST00000641351.2; ENSP00000493028.1; ENSG00000197309.4.
DR Ensembl; ENST00000641546.1; ENSP00000493231.1; ENSG00000197309.4.
DR MANE-Select; ENST00000641351.3; ENSP00000493028.1; NM_001355213.3; NP_001342142.1.
DR UCSC; uc001pzv.3; human.
DR GeneCards; OR10D3; -.
DR HGNC; HGNC:8168; OR10D3.
DR HPA; ENSG00000197309; Not detected.
DR neXtProt; NX_Q8NH80; -.
DR VEuPathDB; HostDB:ENSG00000197309; -.
DR eggNOG; ENOG502SH9P; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH80; -.
DR OMA; FALPYCG; -.
DR PhylomeDB; Q8NH80; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NH80; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NH80; -.
DR ChiTaRS; OR10D3; human.
DR Pharos; Q8NH80; Tdark.
DR PRO; PR:Q8NH80; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH80; protein.
DR Bgee; ENSG00000197309; Expressed in colonic epithelium and 3 other tissues.
DR Genevisible; Q8NH80; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..312
FT /note="Putative olfactory receptor 10D3"
FT /id="PRO_0000349228"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 97..179
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 134
FT /note="V -> A (in Ref. 2; X64983)"
FT /evidence="ECO:0000305"
FT CONFLICT 202
FT /note="N -> S (in Ref. 2; X64983)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 34812 MW; 2C08D37947CA71AC CRC64;
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM SSARLHTPMY
FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ LFFFHFLGSI ECFLFTVMAY
DRFTAICYPL RYTVIMNPRI CVALAVGTWL LGCIHSSILT SLTFTLPYCG PNEVDHFFCD
IPALLPLACA DTSLAQRVSF TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST
CSAHLIAILC AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
TILHRTGHVP ES
