O10G2_HUMAN
ID O10G2_HUMAN Reviewed; 310 AA.
AC Q8NGC3; B2RPD0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Olfactory receptor 10G2;
GN Name=OR10G2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ARG-85; HIS-136; ARG-187;
RP ARG-209; HIS-228 AND ALA-236.
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ARG-85; HIS-136;
RP ARG-187; ARG-209; HIS-228 AND ALA-236.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G2";
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DR EMBL; AB065894; BAC06110.1; -; Genomic_DNA.
DR EMBL; CH471078; EAW66374.1; -; Genomic_DNA.
DR EMBL; BC137371; AAI37372.1; -; mRNA.
DR EMBL; BC137382; AAI37383.1; -; mRNA.
DR CCDS; CCDS32047.1; -.
DR RefSeq; NP_001005466.2; NM_001005466.2.
DR AlphaFoldDB; Q8NGC3; -.
DR STRING; 9606.ENSP00000445383; -.
DR GlyGen; Q8NGC3; 1 site.
DR BioMuta; OR10G2; -.
DR DMDM; 38372664; -.
DR MassIVE; Q8NGC3; -.
DR PaxDb; Q8NGC3; -.
DR PeptideAtlas; Q8NGC3; -.
DR PRIDE; Q8NGC3; -.
DR Antibodypedia; 58800; 107 antibodies from 19 providers.
DR Ensembl; ENST00000542433.1; ENSP00000445383.1; ENSG00000255582.1.
DR GeneID; 26534; -.
DR KEGG; hsa:26534; -.
DR MANE-Select; ENST00000542433.1; ENSP00000445383.1; NM_001005466.2; NP_001005466.2.
DR UCSC; uc032ate.2; human.
DR CTD; 26534; -.
DR GeneCards; OR10G2; -.
DR HGNC; HGNC:8170; OR10G2.
DR HPA; ENSG00000255582; Not detected.
DR neXtProt; NX_Q8NGC3; -.
DR PharmGKB; PA31969; -.
DR VEuPathDB; HostDB:ENSG00000255582; -.
DR eggNOG; ENOG502SI7K; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGC3; -.
DR PhylomeDB; Q8NGC3; -.
DR TreeFam; TF336512; -.
DR PathwayCommons; Q8NGC3; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NGC3; Tdark.
DR PRO; PR:Q8NGC3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC3; protein.
DR Bgee; ENSG00000255582; Expressed in lymph node and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR InterPro; IPR030785; OR10G2.
DR PANTHER; PTHR26453:SF666; PTHR26453:SF666; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 10G2"
FT /id="PRO_0000150695"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..58
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 59..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 6
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 67
FT /note="L -> F (in dbSNP:rs10146821)"
FT /id="VAR_053270"
FT VARIANT 85
FT /note="L -> R (in dbSNP:rs41314525)"
FT /id="VAR_053271"
FT VARIANT 136
FT /note="R -> H (in dbSNP:rs10138694)"
FT /id="VAR_085741"
FT VARIANT 187
FT /note="P -> R (in dbSNP:rs35963889)"
FT /id="VAR_053272"
FT VARIANT 209
FT /note="G -> R (in dbSNP:rs12894405)"
FT /id="VAR_053273"
FT VARIANT 228
FT /note="N -> H (in dbSNP:rs200792644)"
FT /id="VAR_085742"
FT VARIANT 236
FT /note="T -> A (in dbSNP:rs41307110)"
FT /id="VAR_085743"
SQ SEQUENCE 310 AA; 34297 MW; 7F09580D7F31C405 CRC64;
MGKTKNTSLD AVVTDFILLG LSHPPNLRSL LFLVFFIIYI LTQLGNLLIL LTMWADPKLC
ARPMYILLGV LSFLDMWLSS VTVPLLILDF TPSIKAIPFG GCVAQLYFFH FLGSTQCFLY
TLMAYDRYLA ICQPLRYPVL MNGRLCTVLV AGAWVAGSMH GSIQATLTFR LPYCGPNQVD
YFICDIPAVL RLACADTTVN ELVTFVDVGV VAASCFMLIL LSYANIVNAI LKIRTTDGRR
RAFSTCGSHL IVVTVYYVPC IFIYLRAGSK DPLDGAAAVF YTVVTPLLNP LIYTLRNQEV
KSALKRITAG
