O10G3_HUMAN
ID O10G3_HUMAN Reviewed; 313 AA.
AC Q8NGC4; Q6IET7; Q96R77;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 10G3;
DE AltName: Full=Olfactory receptor OR14-40;
GN Name=OR10G3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-282.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G3";
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DR EMBL; AB065893; BAC06109.1; -; Genomic_DNA.
DR EMBL; AF399566; AAK95051.1; -; Genomic_DNA.
DR EMBL; BK004525; DAA04923.1; -; Genomic_DNA.
DR CCDS; CCDS32046.1; -.
DR RefSeq; NP_001005465.1; NM_001005465.1.
DR AlphaFoldDB; Q8NGC4; -.
DR SMR; Q8NGC4; -.
DR BioGRID; 117735; 7.
DR STRING; 9606.ENSP00000302437; -.
DR GlyGen; Q8NGC4; 2 sites.
DR iPTMnet; Q8NGC4; -.
DR PhosphoSitePlus; Q8NGC4; -.
DR BioMuta; OR10G3; -.
DR DMDM; 38372665; -.
DR PaxDb; Q8NGC4; -.
DR PeptideAtlas; Q8NGC4; -.
DR PRIDE; Q8NGC4; -.
DR ProteomicsDB; 73474; -.
DR Antibodypedia; 7569; 14 antibodies from 11 providers.
DR DNASU; 26533; -.
DR Ensembl; ENST00000641040.1; ENSP00000493245.1; ENSG00000169208.3.
DR Ensembl; ENST00000641185.1; ENSP00000492973.1; ENSG00000169208.3.
DR GeneID; 26533; -.
DR KEGG; hsa:26533; -.
DR MANE-Select; ENST00000641040.1; ENSP00000493245.1; NM_001005465.2; NP_001005465.1.
DR UCSC; uc010tmb.2; human.
DR CTD; 26533; -.
DR GeneCards; OR10G3; -.
DR HGNC; HGNC:8171; OR10G3.
DR HPA; ENSG00000169208; Not detected.
DR neXtProt; NX_Q8NGC4; -.
DR OpenTargets; ENSG00000169208; -.
DR PharmGKB; PA31970; -.
DR VEuPathDB; HostDB:ENSG00000169208; -.
DR eggNOG; ENOG502SHXU; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGC4; -.
DR OMA; KRMIGGP; -.
DR OrthoDB; 890998at2759; -.
DR PhylomeDB; Q8NGC4; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGC4; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26533; 8 hits in 674 CRISPR screens.
DR GeneWiki; OR10G3; -.
DR GenomeRNAi; 26533; -.
DR Pharos; Q8NGC4; Tdark.
DR PRO; PR:Q8NGC4; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NGC4; protein.
DR Bgee; ENSG00000169208; Expressed in right lung and 85 other tissues.
DR ExpressionAtlas; Q8NGC4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 10G3"
FT /id="PRO_0000150696"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 73
FT /note="S -> G (in dbSNP:rs17792778)"
FT /id="VAR_053274"
SQ SEQUENCE 313 AA; 35055 MW; D36D8D1B069F3C27 CRC64;
MERINSTLLT AFILTGIPYP LRLRTLFFVF FFLIYILTQL GNLLILITVW ADPRLHARPM
YIFLGVLSVI DMSISSIIVP RLMMNFTLGV KPIPFGGCVA QLYFYHFLGS TQCFLYTLMA
YDRYLAICQP LRYPVLMTAK LSALLVAGAW MAGSIHGALQ AILTFRLPYC GPNQVDYFFC
DIPAVLRLAC ADTTVNELVT FVDIGVVVAS CFSLILLSYI QIIQAILRIH TADGRRRAFS
TCGAHVTVVT VYYVPCAFIY LRPETNSPLD GAAALVPTAI TPFLNPLIYT LRNQEVKLAL
KRMLRSPRTP SEV
