O10G4_HUMAN
ID O10G4_HUMAN Reviewed; 311 AA.
AC Q8NGN3; Q6IEW0;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 10G4;
DE AltName: Full=Olfactory receptor OR11-278;
GN Name=OR10G4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8NGN3; Q86XA6: B4GALT1; NbExp=3; IntAct=EBI-17208485, EBI-18325557;
CC Q8NGN3; P30050-2: RPL12; NbExp=3; IntAct=EBI-17208485, EBI-17208508;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G4";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB065757; BAC05977.1; -; Genomic_DNA.
DR EMBL; BK004502; DAA04900.1; -; Genomic_DNA.
DR CCDS; CCDS31702.1; -.
DR RefSeq; NP_001004462.1; NM_001004462.1.
DR AlphaFoldDB; Q8NGN3; -.
DR SMR; Q8NGN3; -.
DR BioGRID; 133478; 2.
DR IntAct; Q8NGN3; 2.
DR STRING; 9606.ENSP00000325076; -.
DR GlyGen; Q8NGN3; 1 site.
DR iPTMnet; Q8NGN3; -.
DR PhosphoSitePlus; Q8NGN3; -.
DR BioMuta; OR10G4; -.
DR DMDM; 38372733; -.
DR PaxDb; Q8NGN3; -.
DR PRIDE; Q8NGN3; -.
DR Antibodypedia; 56778; 45 antibodies from 15 providers.
DR DNASU; 390264; -.
DR Ensembl; ENST00000641521.1; ENSP00000493354.1; ENSG00000254737.3.
DR Ensembl; ENST00000641722.1; ENSP00000493036.1; ENSG00000254737.3.
DR GeneID; 390264; -.
DR KEGG; hsa:390264; -.
DR MANE-Select; ENST00000641722.1; ENSP00000493036.1; NM_001004462.2; NP_001004462.1.
DR UCSC; uc010sac.2; human.
DR CTD; 390264; -.
DR GeneCards; OR10G4; -.
DR HGNC; HGNC:14809; OR10G4.
DR HPA; ENSG00000254737; Not detected.
DR neXtProt; NX_Q8NGN3; -.
DR OpenTargets; ENSG00000254737; -.
DR PharmGKB; PA31971; -.
DR VEuPathDB; HostDB:ENSG00000254737; -.
DR eggNOG; ENOG502SI4A; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGN3; -.
DR OMA; MTTFILM; -.
DR OrthoDB; 1189559at2759; -.
DR PhylomeDB; Q8NGN3; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGN3; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390264; 11 hits in 632 CRISPR screens.
DR GeneWiki; OR10G4; -.
DR GenomeRNAi; 390264; -.
DR Pharos; Q8NGN3; Tdark.
DR PRO; PR:Q8NGN3; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN3; protein.
DR Bgee; ENSG00000254737; Expressed in body of pancreas and 4 other tissues.
DR ExpressionAtlas; Q8NGN3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR030779; 10G4/10G9.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453:SF6; PTHR26453:SF6; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 10G4"
FT /id="PRO_0000150697"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 24
FT /note="L -> P (in dbSNP:rs547068)"
FT /id="VAR_053275"
FT VARIANT 101
FT /note="Y -> C (in dbSNP:rs4474449)"
FT /id="VAR_060025"
FT VARIANT 134
FT /note="M -> V (in dbSNP:rs1893766)"
FT /id="VAR_053276"
FT VARIANT 146
FT /note="G -> C (in dbSNP:rs503223)"
FT /id="VAR_060026"
FT VARIANT 146
FT /note="G -> R (in dbSNP:rs503223)"
FT /id="VAR_060027"
FT VARIANT 146
FT /note="G -> S (in dbSNP:rs503223)"
FT /id="VAR_060028"
FT VARIANT 181
FT /note="P -> S (in dbSNP:rs1893764)"
FT /id="VAR_053277"
FT VARIANT 195
FT /note="V -> E (in dbSNP:rs4084209)"
FT /id="VAR_034283"
FT VARIANT 226
FT /note="R -> Q (in dbSNP:rs11219408)"
FT /id="VAR_053278"
FT VARIANT 235
FT /note="R -> G (in dbSNP:rs4936880)"
FT /id="VAR_034284"
FT VARIANT 295
FT /note="K -> Q (in dbSNP:rs4936881)"
FT /id="VAR_053279"
SQ SEQUENCE 311 AA; 34569 MW; A46CBCE6EF461752 CRC64;
MSNASLVTAF ILTGLPHAPG LDALLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF
LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD
RYLAISYPLR YTSMMSGSRC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA
PPILKLACAD TSANVMVIFV DIGIVASGCF VLIVLSYVSI VCSILRIRTS DGRRRAFQTC
ASHCIVVLCF FVPCVVIYLR PGSMDAMDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK
LRDKVAHPQR K
