O10G6_HUMAN
ID O10G6_HUMAN Reviewed; 332 AA.
AC Q8NH81;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Olfactory receptor 10G6;
DE AltName: Full=Olfactory receptor OR11-280;
GN Name=OR10G6; Synonyms=OR10G6P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [3]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G6";
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DR EMBL; AB065508; BAC05756.1; -; Genomic_DNA.
DR EMBL; BK004312; DAA04710.1; -; Genomic_DNA.
DR CCDS; CCDS86256.1; -.
DR AlphaFoldDB; Q8NH81; -.
DR SMR; Q8NH81; -.
DR STRING; 9606.ENSP00000477445; -.
DR GlyGen; Q8NH81; 1 site.
DR BioMuta; OR10G6; -.
DR DMDM; 74760323; -.
DR PeptideAtlas; Q8NH81; -.
DR PRIDE; Q8NH81; -.
DR Antibodypedia; 71798; 13 antibodies from 9 providers.
DR Ensembl; ENST00000307002.3; ENSP00000477445.1; ENSG00000198674.3.
DR MANE-Select; ENST00000307002.3; ENSP00000477445.1; NM_001355219.1; NP_001342148.1.
DR UCSC; uc058iqj.1; human.
DR GeneCards; OR10G6; -.
DR HGNC; HGNC:14836; OR10G6.
DR HPA; ENSG00000198674; Not detected.
DR neXtProt; NX_Q8NH81; -.
DR VEuPathDB; HostDB:ENSG00000198674; -.
DR eggNOG; ENOG502SI7K; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NH81; -.
DR OMA; MTISCAI; -.
DR PhylomeDB; Q8NH81; -.
DR PathwayCommons; Q8NH81; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR Pharos; Q8NH81; Tdark.
DR PRO; PR:Q8NH81; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NH81; protein.
DR ExpressionAtlas; Q8NH81; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..332
FT /note="Olfactory receptor 10G6"
FT /id="PRO_0000150698"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..120
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 142..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..218
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..238
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..290
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 118..210
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 332 AA; 36823 MW; 55CA595003AAB978 CRC64;
MLEGVEHLLL LLLLTDVNSK ELQSGNQTSV SHFILVGLHH PPQLGAPLFL AFLVIYLLTV
SGNGLIILTV LVDIRLHRPM CLFLCHLSFL DMTISCAIVP KMLAGFLLGS RIISFGGCVI
QLFSFHFLGC TECFLYTLMA YDRFLAICKP LHYATIMTHR VCNSLALGTW LGGTIHSLFQ
TSFVFRLPFC GPNRVDYIFC DIPAMLRLAC ADTAINELVT FADIGFLALT CFMLILTSYG
YIVAAILRIP SADGRRNAFS TCAAHLTVVI VYYVPCTFIY LRPCSQEPLD GVVAVFYTVI
TPLLNSIIYT LCNKEMKAAL QRLGGHKEVQ PH
