O10G7_HUMAN
ID O10G7_HUMAN Reviewed; 311 AA.
AC Q8NGN6; Q6IFE8;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Olfactory receptor 10G7;
DE AltName: Full=Olfactory receptor OR11-283;
GN Name=OR10G7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G7";
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DR EMBL; AB065754; BAC05974.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67568.1; -; Genomic_DNA.
DR EMBL; BK004314; DAA04712.1; -; Genomic_DNA.
DR CCDS; CCDS31705.1; -.
DR RefSeq; NP_001004463.1; NM_001004463.1.
DR AlphaFoldDB; Q8NGN6; -.
DR SMR; Q8NGN6; -.
DR STRING; 9606.ENSP00000329689; -.
DR GlyGen; Q8NGN6; 1 site.
DR iPTMnet; Q8NGN6; -.
DR PhosphoSitePlus; Q8NGN6; -.
DR BioMuta; OR10G7; -.
DR DMDM; 38372736; -.
DR PaxDb; Q8NGN6; -.
DR PeptideAtlas; Q8NGN6; -.
DR PRIDE; Q8NGN6; -.
DR Antibodypedia; 56785; 46 antibodies from 15 providers.
DR DNASU; 390265; -.
DR Ensembl; ENST00000641585.1; ENSP00000492905.1; ENSG00000182634.9.
DR GeneID; 390265; -.
DR KEGG; hsa:390265; -.
DR MANE-Select; ENST00000641585.1; ENSP00000492905.1; NM_001004463.2; NP_001004463.1.
DR UCSC; uc001pzq.2; human.
DR CTD; 390265; -.
DR GeneCards; OR10G7; -.
DR HGNC; HGNC:14842; OR10G7.
DR HPA; ENSG00000182634; Not detected.
DR neXtProt; NX_Q8NGN6; -.
DR OpenTargets; ENSG00000182634; -.
DR PharmGKB; PA31974; -.
DR VEuPathDB; HostDB:ENSG00000182634; -.
DR eggNOG; ENOG502SI4A; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGN6; -.
DR OMA; LAIYMFT; -.
DR OrthoDB; 1189559at2759; -.
DR PhylomeDB; Q8NGN6; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGN6; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 390265; 8 hits in 619 CRISPR screens.
DR GeneWiki; OR10G7; -.
DR GenomeRNAi; 390265; -.
DR Pharos; Q8NGN6; Tdark.
DR PRO; PR:Q8NGN6; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN6; protein.
DR ExpressionAtlas; Q8NGN6; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 10G7"
FT /id="PRO_0000150699"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 5
FT /note="T -> S (in dbSNP:rs3894197)"
FT /id="VAR_024126"
FT VARIANT 13
FT /note="T -> M (in dbSNP:rs11827843)"
FT /id="VAR_048060"
FT VARIANT 18
FT /note="A -> V (in dbSNP:rs3894198)"
FT /id="VAR_048061"
FT VARIANT 20
FT /note="G -> A (in dbSNP:rs3894199)"
FT /id="VAR_048062"
FT VARIANT 28
FT /note="I -> V (in dbSNP:rs11219420)"
FT /id="VAR_048063"
FT VARIANT 90
FT /note="T -> A (in dbSNP:rs470208)"
FT /id="VAR_048064"
FT VARIANT 136
FT /note="T -> S (in dbSNP:rs513591)"
FT /id="VAR_034285"
SQ SEQUENCE 311 AA; 34517 MW; D507B511CF7B1D22 CRC64;
MSNATLLTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF
LTNLSFIDMW FSTVTVPKML MTLVSPSGRT ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD
RYLAISYPLR YTNMMTGRSC ALLATGTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYFCDA
PPILKLACAD TSANEMVIFV NIGLVASGCF VLIVLSYVSI VCSILRIRTS EGRHRAFQTC
ASHCIVVLCF FGPGLFIYLR PGSRDALHGV VAVFYTTLTP LFNPVVYTLR NKEVKKALLK
LKNGSVFAQG E
