O10G8_HUMAN
ID O10G8_HUMAN Reviewed; 311 AA.
AC Q8NGN5; B2RNJ3; Q6IEV2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Olfactory receptor 10G8;
DE AltName: Full=Olfactory receptor OR11-282;
GN Name=OR10G8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G8";
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DR EMBL; AB065755; BAC05975.1; -; Genomic_DNA.
DR EMBL; CH471065; EAW67567.1; -; Genomic_DNA.
DR EMBL; BC136917; AAI36918.1; -; mRNA.
DR EMBL; BC136920; AAI36921.1; -; mRNA.
DR EMBL; BK004510; DAA04908.1; -; Genomic_DNA.
DR CCDS; CCDS31704.1; -.
DR RefSeq; NP_001004464.1; NM_001004464.1.
DR AlphaFoldDB; Q8NGN5; -.
DR SMR; Q8NGN5; -.
DR BioGRID; 128587; 15.
DR STRING; 9606.ENSP00000389072; -.
DR GlyGen; Q8NGN5; 1 site.
DR iPTMnet; Q8NGN5; -.
DR PhosphoSitePlus; Q8NGN5; -.
DR BioMuta; OR10G8; -.
DR DMDM; 38372735; -.
DR MassIVE; Q8NGN5; -.
DR PaxDb; Q8NGN5; -.
DR PeptideAtlas; Q8NGN5; -.
DR PRIDE; Q8NGN5; -.
DR Antibodypedia; 67320; 61 antibodies from 17 providers.
DR DNASU; 219869; -.
DR Ensembl; ENST00000431524.1; ENSP00000389072.1; ENSG00000234560.5.
DR Ensembl; ENST00000641224.2; ENSP00000493087.1; ENSG00000234560.5.
DR GeneID; 219869; -.
DR KEGG; hsa:219869; -.
DR MANE-Select; ENST00000641224.2; ENSP00000493087.1; NM_001004464.2; NP_001004464.1.
DR UCSC; uc001pzp.2; human.
DR CTD; 219869; -.
DR GeneCards; OR10G8; -.
DR HGNC; HGNC:14845; OR10G8.
DR HPA; ENSG00000234560; Not detected.
DR neXtProt; NX_Q8NGN5; -.
DR PharmGKB; PA31975; -.
DR VEuPathDB; HostDB:ENSG00000234560; -.
DR eggNOG; ENOG502SI4A; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGN5; -.
DR OMA; TECFLYA; -.
DR OrthoDB; 1189559at2759; -.
DR PhylomeDB; Q8NGN5; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGN5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219869; 6 hits in 666 CRISPR screens.
DR GeneWiki; OR10G8; -.
DR GenomeRNAi; 219869; -.
DR Pharos; Q8NGN5; Tdark.
DR PRO; PR:Q8NGN5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN5; protein.
DR Bgee; ENSG00000234560; Expressed in sural nerve.
DR ExpressionAtlas; Q8NGN5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 10G8"
FT /id="PRO_0000150700"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 311 AA; 34519 MW; 1F3214FD463A7CFD CRC64;
MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF
LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD
RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA
PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC
ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK
LKDKVAHSQS K
