O10G9_HUMAN
ID O10G9_HUMAN Reviewed; 311 AA.
AC Q8NGN4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Olfactory receptor 10G9;
DE AltName: Full=Olfactory receptor 10G10;
GN Name=OR10G9; Synonyms=OR10G10P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10G9";
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DR EMBL; AB065756; BAC05976.1; -; Genomic_DNA.
DR CCDS; CCDS31703.1; -.
DR RefSeq; NP_001001953.1; NM_001001953.1.
DR AlphaFoldDB; Q8NGN4; -.
DR SMR; Q8NGN4; -.
DR STRING; 9606.ENSP00000364164; -.
DR iPTMnet; Q8NGN4; -.
DR PhosphoSitePlus; Q8NGN4; -.
DR BioMuta; OR10G9; -.
DR DMDM; 38372734; -.
DR PaxDb; Q8NGN4; -.
DR PeptideAtlas; Q8NGN4; -.
DR PRIDE; Q8NGN4; -.
DR Antibodypedia; 56782; 114 antibodies from 21 providers.
DR DNASU; 219870; -.
DR Ensembl; ENST00000375024.1; ENSP00000364164.1; ENSG00000236981.1.
DR GeneID; 219870; -.
DR KEGG; hsa:219870; -.
DR MANE-Select; ENST00000375024.1; ENSP00000364164.1; NM_001001953.1; NP_001001953.1.
DR UCSC; uc010sad.2; human.
DR CTD; 219870; -.
DR GeneCards; OR10G9; -.
DR HGNC; HGNC:15129; OR10G9.
DR HPA; ENSG00000236981; Not detected.
DR neXtProt; NX_Q8NGN4; -.
DR PharmGKB; PA31976; -.
DR VEuPathDB; HostDB:ENSG00000236981; -.
DR eggNOG; ENOG502SI4A; Eukaryota.
DR GeneTree; ENSGT01050000244869; -.
DR HOGENOM; CLU_012526_8_1_1; -.
DR InParanoid; Q8NGN4; -.
DR OMA; ISFRSCV; -.
DR OrthoDB; 1189559at2759; -.
DR PhylomeDB; Q8NGN4; -.
DR TreeFam; TF337251; -.
DR PathwayCommons; Q8NGN4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219870; 6 hits in 596 CRISPR screens.
DR GeneWiki; OR10G9; -.
DR GenomeRNAi; 219870; -.
DR Pharos; Q8NGN4; Tdark.
DR PRO; PR:Q8NGN4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGN4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR InterPro; IPR030779; 10G4/10G9.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26453:SF6; PTHR26453:SF6; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 10G9"
FT /id="PRO_0000150701"
FT TOPO_DOM 1..23
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..236
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 134
FT /note="M -> V (in dbSNP:rs12366219)"
FT /id="VAR_053280"
FT VARIANT 136
FT /note="S -> T (in dbSNP:rs17128190)"
FT /id="VAR_034286"
FT VARIANT 172
FT /note="Q -> R (in dbSNP:rs11219413)"
FT /id="VAR_034287"
FT VARIANT 228
FT /note="H -> R (in dbSNP:rs12221656)"
FT /id="VAR_060029"
SQ SEQUENCE 311 AA; 34574 MW; 03031B6522DB92AE CRC64;
MSKTSLVTAF ILTGLPHAPG LDAPLFGIFL VVYVLTVLGN LLILLVIRVD SHLHTPMYYF
LTNLSFIDMW FSTVTVPKML MTLVSPSGRA ISFHSCVAQL YFFHFLGSTE CFLYTVMSYD
RYLAISYPLR YTSMMSGSRC ALLATSTWLS GSLHSAVQTI LTFHLPYCGP NQIQHYLCDA
PPILKLACAD TSANEMVIFV DIGLVASGCF LLIVLSYVSI VCSILRIHTS EGRHRAFQTC
ASHCIVVLCF FVPCVFIYLR PGSRDVVDGV VAIFYTVLTP LLNPVVYTLR NKEVKKAVLK
LRDKVAHSQG E
