O10H1_HUMAN
ID O10H1_HUMAN Reviewed; 318 AA.
AC Q9Y4A9; Q6IFQ2; Q96R59;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Olfactory receptor 10H1;
DE AltName: Full=Olfactory receptor OR19-27;
GN Name=OR10H1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H1";
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DR EMBL; AC004510; AAC08454.1; -; Genomic_DNA.
DR EMBL; BC130360; AAI30361.1; -; mRNA.
DR EMBL; BC132969; AAI32970.1; -; mRNA.
DR EMBL; AF399584; AAK95069.1; -; Genomic_DNA.
DR EMBL; BK004210; DAA04608.1; -; Genomic_DNA.
DR CCDS; CCDS12335.1; -.
DR RefSeq; NP_039228.1; NM_013940.2.
DR RefSeq; XP_011526213.1; XM_011527911.1.
DR AlphaFoldDB; Q9Y4A9; -.
DR SMR; Q9Y4A9; -.
DR BioGRID; 117739; 49.
DR IntAct; Q9Y4A9; 1.
DR STRING; 9606.ENSP00000335596; -.
DR GlyGen; Q9Y4A9; 1 site.
DR PhosphoSitePlus; Q9Y4A9; -.
DR BioMuta; OR10H1; -.
DR DMDM; 14423829; -.
DR MassIVE; Q9Y4A9; -.
DR PaxDb; Q9Y4A9; -.
DR PRIDE; Q9Y4A9; -.
DR Antibodypedia; 54315; 99 antibodies from 21 providers.
DR DNASU; 26539; -.
DR Ensembl; ENST00000334920.3; ENSP00000335596.2; ENSG00000186723.4.
DR Ensembl; ENST00000641419.1; ENSP00000493436.1; ENSG00000186723.4.
DR GeneID; 26539; -.
DR KEGG; hsa:26539; -.
DR MANE-Select; ENST00000641419.1; ENSP00000493436.1; NM_013940.4; NP_039228.1.
DR UCSC; uc002nbq.3; human.
DR CTD; 26539; -.
DR GeneCards; OR10H1; -.
DR HGNC; HGNC:8172; OR10H1.
DR HPA; ENSG00000186723; Tissue enhanced (brain).
DR neXtProt; NX_Q9Y4A9; -.
DR PharmGKB; PA31977; -.
DR VEuPathDB; HostDB:ENSG00000186723; -.
DR eggNOG; ENOG502SJHK; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q9Y4A9; -.
DR OMA; SIFHLTF; -.
DR OrthoDB; 891133at2759; -.
DR PhylomeDB; Q9Y4A9; -.
DR TreeFam; TF337675; -.
DR PathwayCommons; Q9Y4A9; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q9Y4A9; -.
DR BioGRID-ORCS; 26539; 12 hits in 601 CRISPR screens.
DR ChiTaRS; OR10H1; human.
DR GeneWiki; OR10H1; -.
DR GenomeRNAi; 26539; -.
DR Pharos; Q9Y4A9; Tdark.
DR PRO; PR:Q9Y4A9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9Y4A9; protein.
DR Bgee; ENSG00000186723; Expressed in buccal mucosa cell and 9 other tissues.
DR ExpressionAtlas; Q9Y4A9; baseline and differential.
DR Genevisible; Q9Y4A9; HS.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Olfactory receptor 10H1"
FT /id="PRO_0000150702"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 16
FT /note="G -> R (in dbSNP:rs4808383)"
FT /id="VAR_024127"
FT VARIANT 65
FT /note="A -> V (in dbSNP:rs4808382)"
FT /id="VAR_054124"
FT VARIANT 175
FT /note="H -> Q (in dbSNP:rs1859298)"
FT /id="VAR_054125"
SQ SEQUENCE 318 AA; 35254 MW; D289E18D8A56FC57 CRC64;
MQRANHSTVT QFILVGFSVF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHTPMY
LFLCALSVSE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY
DRYVAICHPL RYNVLMSPRG CACLVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFACH
VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS
TCASHLTVVV VHYGFASVIY LKPKSPQSLE GDTLMGITYT VLTPFLSPII FSLRNKELKV
AMKKTFFSKL YPEKNVMM
