ID   ARPIN_DICDI             Reviewed;         224 AA.
AC   Q54F87;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Arpin;
GN   Name=arpin; ORFNames=DDB_G0291009;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=24132237; DOI=10.1038/nature12611;
RA   Dang I., Gorelik R., Sousa-Blin C., Derivery E., Guerin C., Linkner J.,
RA   Nemethova M., Dumortier J.G., Giger F.A., Chipysheva T.A., Ermilova V.D.,
RA   Vacher S., Campanacci V., Herrada I., Planson A.G., Fetics S., Henriot V.,
RA   David V., Oguievetskaia K., Lakisic G., Pierre F., Steffen A., Boyreau A.,
RA   Peyrieras N., Rottner K., Zinn-Justin S., Cherfils J., Bieche I.,
RA   Alexandrova A.Y., David N.B., Small J.V., Faix J., Blanchoin L.,
RA   Gautreau A.;
RT   "Inhibitory signalling to the Arp2/3 complex steers cell migration.";
RL   Nature 503:281-284(2013).
CC   -!- FUNCTION: Regulates actin polymerization by inhibiting the actin-
CC       nucleating activity of the Arp2/3 complex (By similarity). Involved in
CC       steering cell migration by controlling its directional persistence.
CC       {ECO:0000250, ECO:0000269|PubMed:24132237}.
CC   -!- SUBUNIT: Associates with the Arp2/3 complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Arpin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000174; EAL61935.1; -; Genomic_DNA.
DR   RefSeq; XP_635450.1; XM_630358.1.
DR   AlphaFoldDB; Q54F87; -.
DR   PaxDb; Q54F87; -.
DR   EnsemblProtists; EAL61935; EAL61935; DDB_G0291009.
DR   GeneID; 8627950; -.
DR   KEGG; ddi:DDB_G0291009; -.
DR   dictyBase; DDB_G0291009; arpin.
DR   eggNOG; ENOG502RH14; Eukaryota.
DR   HOGENOM; CLU_106544_0_0_1; -.
DR   InParanoid; Q54F87; -.
DR   OMA; HLMSSYK; -.
DR   PhylomeDB; Q54F87; -.
DR   PRO; PR:Q54F87; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0033058; P:directional locomotion; IMP:UniProtKB.
DR   GO; GO:0051126; P:negative regulation of actin nucleation; IBA:GO_Central.
DR   GO; GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
DR   InterPro; IPR018889; Arpin.
DR   PANTHER; PTHR31199; PTHR31199; 1.
DR   Pfam; PF10574; UPF0552; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..224
FT                   /note="Arpin"
FT                   /id="PRO_0000327664"
SQ   SEQUENCE   224 AA;  25384 MW;  FD758E61F611BDF4 CRC64;
     MSSSTNYSGT FTKERFCGGD GFIVEGILQK HNIHTVFLQA KQPLQDTVLP TRYVAITIEF
     DNAVKRNWKD GVEIPPKMTR ATAITKGYLN KFDRVQATLV DKINADQLSV AISDGNKNSS
     LPSNFHDDAI KNLHPNKKNY FEFWADVDKF SHKIFKSGDE VRIKTIGDSI FVDSVVKMDS
     NNIANFSGDS NLGDSFASNI MKRYDQIESN NQQQQEEEDD DEWK