O10H3_HUMAN
ID O10H3_HUMAN Reviewed; 316 AA.
AC O60404; Q2HIZ3; Q6IFQ0;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Olfactory receptor 10H3;
DE AltName: Full=Olfactory receptor OR19-24;
GN Name=OR10H3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT MET-224.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [4]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H3";
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DR EMBL; AC004597; AAC14389.1; -; Genomic_DNA.
DR EMBL; BC106707; AAI06708.1; -; mRNA.
DR EMBL; BC113844; AAI13845.1; -; mRNA.
DR EMBL; BK004212; DAA04610.1; -; Genomic_DNA.
DR CCDS; CCDS12334.1; -.
DR RefSeq; NP_039226.1; NM_013938.1.
DR AlphaFoldDB; O60404; -.
DR SMR; O60404; -.
DR BioGRID; 117734; 8.
DR IntAct; O60404; 6.
DR STRING; 9606.ENSP00000307130; -.
DR iPTMnet; O60404; -.
DR PhosphoSitePlus; O60404; -.
DR BioMuta; OR10H3; -.
DR PaxDb; O60404; -.
DR PeptideAtlas; O60404; -.
DR PRIDE; O60404; -.
DR Antibodypedia; 54307; 21 antibodies from 11 providers.
DR DNASU; 26532; -.
DR Ensembl; ENST00000641646.1; ENSP00000493287.1; ENSG00000171936.3.
DR GeneID; 26532; -.
DR KEGG; hsa:26532; -.
DR MANE-Select; ENST00000641646.1; ENSP00000493287.1; NM_013938.2; NP_039226.1.
DR UCSC; uc010xoq.2; human.
DR CTD; 26532; -.
DR GeneCards; OR10H3; -.
DR HGNC; HGNC:8174; OR10H3.
DR HPA; ENSG00000171936; Not detected.
DR neXtProt; NX_O60404; -.
DR PharmGKB; PA31979; -.
DR VEuPathDB; HostDB:ENSG00000171936; -.
DR eggNOG; ENOG502SJHK; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; O60404; -.
DR OMA; TVWIERR; -.
DR OrthoDB; 970259at2759; -.
DR PhylomeDB; O60404; -.
DR TreeFam; TF338279; -.
DR PathwayCommons; O60404; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; O60404; -.
DR BioGRID-ORCS; 26532; 8 hits in 635 CRISPR screens.
DR GeneWiki; OR10H3; -.
DR GenomeRNAi; 26532; -.
DR Pharos; O60404; Tdark.
DR PRO; PR:O60404; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; O60404; protein.
DR Bgee; ENSG00000171936; Expressed in pancreatic ductal cell and 5 other tissues.
DR ExpressionAtlas; O60404; baseline and differential.
DR Genevisible; O60404; HS.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 10H3"
FT /id="PRO_0000150704"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 7
FT /note="R -> S (in dbSNP:rs1966357)"
FT /id="VAR_024128"
FT VARIANT 14
FT /note="L -> I (in dbSNP:rs2240227)"
FT /id="VAR_034288"
FT VARIANT 54
FT /note="R -> H (in dbSNP:rs11670007)"
FT /id="VAR_034289"
FT VARIANT 224
FT /note="V -> M (in dbSNP:rs2240228)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_020381"
FT VARIANT 293
FT /note="S -> N (in dbSNP:rs2240229)"
FT /id="VAR_020382"
SQ SEQUENCE 316 AA; 35721 MW; D055291FB9B49BC3 CRC64;
MPGQNYRTIS EFILSGFSAF PQQLLPVLFL LYLLMFLFTL LGNLLIMATV WIERRLHTPM
YLFLCALSIS EILFTVAITP RMLADLLFTH RSITFVACAI QMFFSFMFGF THSFLLMVMG
YDHYVTICHP LHYNMLMSPR GCAHLVAWTW AGGSVMGMMV TMMVFHLTFC GSNVIHHFLC
HVLSLLKLAC GSKTSSVIMG VMLVCVTALI GCLFLIILSF VFIVAAILRI PSAEGRHKTF
STCVSHLTVV VMHYSFASLI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
NAINKNFCRR FCPLSS
