O10H4_HUMAN
ID O10H4_HUMAN Reviewed; 316 AA.
AC Q8NGA5; Q6IFJ2; Q96R57;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Olfactory receptor 10H4;
DE AltName: Full=Olfactory receptor OR19-28;
GN Name=OR10H4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-285.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H4";
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DR EMBL; AB065921; BAC06136.1; -; Genomic_DNA.
DR EMBL; CH471106; EAW84516.1; -; Genomic_DNA.
DR EMBL; AF399586; AAK95071.1; -; Genomic_DNA.
DR EMBL; BK004270; DAA04668.1; -; Genomic_DNA.
DR CCDS; CCDS32941.1; -.
DR RefSeq; NP_001004465.1; NM_001004465.1.
DR AlphaFoldDB; Q8NGA5; -.
DR SMR; Q8NGA5; -.
DR STRING; 9606.ENSP00000318834; -.
DR GlyGen; Q8NGA5; 1 site.
DR iPTMnet; Q8NGA5; -.
DR PhosphoSitePlus; Q8NGA5; -.
DR BioMuta; OR10H4; -.
DR DMDM; 38372653; -.
DR MassIVE; Q8NGA5; -.
DR PaxDb; Q8NGA5; -.
DR PeptideAtlas; Q8NGA5; -.
DR PRIDE; Q8NGA5; -.
DR Antibodypedia; 57129; 99 antibodies from 18 providers.
DR DNASU; 126541; -.
DR Ensembl; ENST00000322107.1; ENSP00000318834.1; ENSG00000176231.2.
DR GeneID; 126541; -.
DR KEGG; hsa:126541; -.
DR MANE-Select; ENST00000322107.1; ENSP00000318834.1; NM_001004465.1; NP_001004465.1.
DR UCSC; uc010xov.2; human.
DR CTD; 126541; -.
DR GeneCards; OR10H4; -.
DR HGNC; HGNC:15388; OR10H4.
DR HPA; ENSG00000176231; Not detected.
DR neXtProt; NX_Q8NGA5; -.
DR OpenTargets; ENSG00000176231; -.
DR PharmGKB; PA31980; -.
DR VEuPathDB; HostDB:ENSG00000176231; -.
DR eggNOG; ENOG502SJHK; Eukaryota.
DR GeneTree; ENSGT01040000240424; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGA5; -.
DR OMA; MSPHDCA; -.
DR OrthoDB; 970259at2759; -.
DR PhylomeDB; Q8NGA5; -.
DR TreeFam; TF338279; -.
DR PathwayCommons; Q8NGA5; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q8NGA5; -.
DR BioGRID-ORCS; 126541; 10 hits in 625 CRISPR screens.
DR GeneWiki; OR10H4; -.
DR GenomeRNAi; 126541; -.
DR Pharos; Q8NGA5; Tdark.
DR PRO; PR:Q8NGA5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NGA5; protein.
DR Bgee; ENSG00000176231; Expressed in heart left ventricle.
DR ExpressionAtlas; Q8NGA5; differential.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..316
FT /note="Olfactory receptor 10H4"
FT /id="PRO_0000150705"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..273
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 100
FT /note="N -> K (in dbSNP:rs16980994)"
FT /id="VAR_034290"
FT VARIANT 144
FT /note="H -> R (in dbSNP:rs16980822)"
FT /id="VAR_034291"
FT VARIANT 281
FT /note="T -> A (in dbSNP:rs11880184)"
FT /id="VAR_062063"
SQ SEQUENCE 316 AA; 35765 MW; E4091E85D5F8A877 CRC64;
MPSQNYSIIS EFNLFGFSAF PQHLLPILFL LYLLMFLFTL LGNLLIMATI WIEHRLHTPM
YLFLCTLSVS EILFTVAITP RMLADLLSTH HSITFVACAN QMFFSFMFGF THSFLLLVMG
YDRYVAICHP LRYNVLMSPR DCAHLVACTW AGGSVMGMMV TTIVFHLTFC GSNVIHHFFC
HVLSLLKLAC ENKTSSVIMG VMLVCVTALI GCLFLIILSY VFIVAAILRI PSAEGRHKTF
STCVSHLTVV VTHYSFASFI YLKPKGLHSM YSDALMATTY TVFTPFLSPI IFSLRNKELK
NAINKNFYRK FCPPSS
