O10H5_HUMAN
ID O10H5_HUMAN Reviewed; 315 AA.
AC Q8NGA6; Q6IFJ0; Q96R60;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Olfactory receptor 10H5;
DE AltName: Full=Olfactory receptor OR19-25;
DE AltName: Full=Olfactory receptor OR19-26;
GN Name=OR10H5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-284.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10H5";
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DR EMBL; AB065920; BAC06135.1; -; Genomic_DNA.
DR EMBL; BC136869; AAI36870.1; -; mRNA.
DR EMBL; AF399583; AAK95068.1; -; Genomic_DNA.
DR EMBL; BK004271; DAA04669.1; -; Genomic_DNA.
DR EMBL; BK004272; DAA04670.1; -; Genomic_DNA.
DR CCDS; CCDS32940.1; -.
DR RefSeq; NP_001004466.1; NM_001004466.1.
DR AlphaFoldDB; Q8NGA6; -.
DR SMR; Q8NGA6; -.
DR IntAct; Q8NGA6; 1.
DR STRING; 9606.ENSP00000310704; -.
DR GlyGen; Q8NGA6; 1 site.
DR iPTMnet; Q8NGA6; -.
DR PhosphoSitePlus; Q8NGA6; -.
DR BioMuta; OR10H5; -.
DR DMDM; 38372654; -.
DR MassIVE; Q8NGA6; -.
DR PaxDb; Q8NGA6; -.
DR PRIDE; Q8NGA6; -.
DR Antibodypedia; 57128; 75 antibodies from 19 providers.
DR DNASU; 284433; -.
DR Ensembl; ENST00000308940.8; ENSP00000310704.8; ENSG00000172519.10.
DR Ensembl; ENST00000642092.2; ENSP00000493242.1; ENSG00000172519.10.
DR GeneID; 284433; -.
DR KEGG; hsa:284433; -.
DR MANE-Select; ENST00000642092.2; ENSP00000493242.1; NM_001004466.2; NP_001004466.1.
DR UCSC; uc010xos.3; human.
DR CTD; 284433; -.
DR GeneCards; OR10H5; -.
DR HGNC; HGNC:15389; OR10H5.
DR HPA; ENSG00000172519; Tissue enhanced (brain).
DR neXtProt; NX_Q8NGA6; -.
DR PharmGKB; PA31981; -.
DR VEuPathDB; HostDB:ENSG00000172519; -.
DR eggNOG; ENOG502SJHK; Eukaryota.
DR GeneTree; ENSGT01050000244853; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGA6; -.
DR OMA; HTIPFAA; -.
DR OrthoDB; 891133at2759; -.
DR PhylomeDB; Q8NGA6; -.
DR TreeFam; TF337675; -.
DR PathwayCommons; Q8NGA6; -.
DR Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 284433; 11 hits in 651 CRISPR screens.
DR ChiTaRS; OR10H5; human.
DR GenomeRNAi; 284433; -.
DR Pharos; Q8NGA6; Tdark.
DR PRO; PR:Q8NGA6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NGA6; protein.
DR Bgee; ENSG00000172519; Expressed in islet of Langerhans.
DR ExpressionAtlas; Q8NGA6; baseline and differential.
DR Genevisible; Q8NGA6; HS.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Olfactory receptor 10H5"
FT /id="PRO_0000150706"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 34900 MW; D43DAFA36E2F8F50 CRC64;
MQGLNHTSVS EFILVGFSAF PHLQLMLFLL FLLMYLFTLL GNLLIMATVW SERSLHMPMY
LFLCALSITE ILYTVAIIPR MLADLLSTQR SIAFLACASQ MFFSFSFGFT HSFLLTVMGY
DRYVAICHPL RYNVLMSLRG CTCRVGCSWA GGLVMGMVVT SAIFHLAFCG HKEIHHFFCH
VPPLLKLACG DDVLVVAKGV GLVCITALLG CFLLILLSYA FIVAAILKIP SAEGRNKAFS
TCASHLTVVV VHYGFASVIY LKPKGPQSPE GDTLMGITYT VLTPFLSPII FSLRNKELKV
AMKKTCFTKL FPQNC
