O10J3_HUMAN
ID O10J3_HUMAN Reviewed; 329 AA.
AC Q5JRS4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Olfactory receptor 10J3;
GN Name=OR10J3; Synonyms=OR10J3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10J3";
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DR EMBL; AL513323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001004467.1; NM_001004467.1.
DR AlphaFoldDB; Q5JRS4; -.
DR SMR; Q5JRS4; -.
DR STRING; 9606.ENSP00000331789; -.
DR GlyGen; Q5JRS4; 1 site.
DR iPTMnet; Q5JRS4; -.
DR PhosphoSitePlus; Q5JRS4; -.
DR BioMuta; OR10J3; -.
DR DMDM; 74762193; -.
DR PaxDb; Q5JRS4; -.
DR PeptideAtlas; Q5JRS4; -.
DR PRIDE; Q5JRS4; -.
DR Antibodypedia; 49616; 136 antibodies from 23 providers.
DR DNASU; 441911; -.
DR GeneID; 441911; -.
DR UCSC; uc010piu.2; human.
DR CTD; 441911; -.
DR DisGeNET; 441911; -.
DR GeneCards; OR10J3; -.
DR HGNC; HGNC:14992; OR10J3.
DR neXtProt; NX_Q5JRS4; -.
DR PharmGKB; PA31984; -.
DR VEuPathDB; HostDB:ENSG00000196266; -.
DR eggNOG; ENOG502T9MC; Eukaryota.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q5JRS4; -.
DR OMA; FSSFRWQ; -.
DR OrthoDB; 909891at2759; -.
DR PhylomeDB; Q5JRS4; -.
DR TreeFam; TF337624; -.
DR PathwayCommons; Q5JRS4; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR SignaLink; Q5JRS4; -.
DR BioGRID-ORCS; 441911; 12 hits in 677 CRISPR screens.
DR ChiTaRS; OR10J3; human.
DR GeneWiki; OR10J3; -.
DR GenomeRNAi; 441911; -.
DR Pharos; Q5JRS4; Tdark.
DR PRO; PR:Q5JRS4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5JRS4; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Olfactory receptor 10J3"
FT /id="PRO_0000150708"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..198
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 235
FT /note="Q -> R (in dbSNP:rs11265165)"
FT /id="VAR_053282"
SQ SEQUENCE 329 AA; 36549 MW; 793EF6620BB3E1AA CRC64;
MPKLNSTFVT EFLFEGFSSF RRQHKLVFFV VFLTLYLLTL SGNVIIMTII RLDHHLHTPM
YFFLCMLSIS ETCYTVAIIP HMLSGLLNPH QPIATQSCAT QLFFYLTFGI NNCFLLTVMG
YDRYVAICNP LRYSVIMGKR ACIQLASGSL GIGLGMAIVQ VTSVFGLPFC DAFVISHFFC
DVRHLLKLAC TDTTVNEIIN FVVSVCVLVL PMGLVFISYV LIISTILKIA SAEGQKKAFA
TCASHLTVVI IHYGCASIIY LKPKSQSSLG QDRLISVTYT HHSPTEPCCV QPEEQGGQRC
SAQSRGAKNS VSLMKRGCEG FSFAFINMY
